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Patient considerations in the management of chronic constipation: focus on prucalopride.

Author: ShinAndrea

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review provides an overview of the preclinical and clinical trial data supporting the efficacy and safety of prucalopride, a selective 5-HT4 receptor agonist, for the treatment of chronic constipation in adults. The review highlights the advantages of prucalopride over older 5-HT4 agonists and its potential as a safe and effective therapeutic option.
Paper Details　
Original Abstract of the Article :
Chronic constipation is a common condition that significantly impacts health care utilization, productivity, and quality of life. Laxatives are commonly used, although often insufficient in restoring normal bowel function or providing adequate relief. There remains a significant need for the develop...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970632/

データ提供：米国国立医学図書館（NLM）

Prucalopride for Chronic Constipation: A New Oasis in the Desert

Chronic constipation is a common and often debilitating condition that can significantly impact quality of life. This review focuses on the efficacy and safety of prucalopride, a novel medication for the treatment of chronic constipation. Prucalopride is a selective 5-HT4 receptor agonist that has been approved by the European Medicine Agency for the management of chronic constipation in adults who have not responded to standard laxatives. The review summarizes the preclinical and clinical trial data supporting the use of prucalopride.

Prucalopride: A New Approach to Treating Chronic Constipation

This review highlights the potential benefits of prucalopride for treating chronic constipation. The drug has been shown to improve bowel function, reduce constipation symptoms, and enhance patient-reported outcomes. The review emphasizes the safety and tolerability of prucalopride, particularly its lack of association with adverse cardiovascular side effects or QT prolongation. This information provides valuable support for the use of prucalopride as a safe and effective therapeutic option for chronic constipation.

Managing Chronic Constipation: Seeking Help and Optimizing Treatment

This review underscores the importance of seeking appropriate medical evaluation and treatment for chronic constipation. If you are struggling with chronic constipation, it is crucial to work with your healthcare provider to determine the best treatment plan for your individual needs. Prucalopride may be a viable option for those who have not responded to traditional laxatives.

Dr.Camel's Conclusion

This review is a refreshing oasis in the desert of chronic constipation. Prucalopride, like a cool spring, offers a new and potentially effective treatment option for managing this debilitating condition. It provides valuable information for both patients and healthcare professionals navigating the challenges of chronic constipation.

Date :
  1. Date Completed 2016-08-16
  2. Date Revised 2020-09-30
Further Info :

Pubmed ID

27528801

DOI: Digital Object Identifier

PMC4970632

Related Literature

Article Analysis
・Side Effects of prucalopride
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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