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Effects of sennosides A + B and bisacodyl on rat large intestine.

Author: Leng-PeschlowE

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Bisacodyl and sennosides A+B both induce laxative effects in rats, but bisacodyl exhibits a prolonged action. While both drugs affect colon motility and secretion, bisacodyl's effect appears to be more driven by fluid secretion than sennosides.
Paper Details　
Original Abstract of the Article :
Oral and intracecal administration of bisacodyl or sennosides A + B (10-100 mg/kg each) to rats induced a similar quantity of soft feces within 24 h and a similar acceleration of large intestinal transit time, but in each case bisacodyl had a prolonged action. Net fluid absorption in the perfused ra...See full text at original site
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引用元：
https://doi.org/10.1159/000138551

データ提供：米国国立医学図書館（NLM）

A Comparative Study of Laxative Action: Senna and Bisacodyl

Laxatives are often used to relieve constipation, a common gastrointestinal condition. This study investigates the effects of sennosides A+B and bisacodyl, two commonly used laxatives, on rat large intestine. The researchers compared the laxative potency, duration of action, and mechanisms of action of these two drugs.

Distinct Mechanisms of Laxative Action

The study revealed that both sennosides A+B and bisacodyl induced similar laxative effects in rats, but with different time courses of action. Bisacodyl exhibited a longer-lasting effect compared to sennosides A+B. The researchers concluded that the differences in duration of action are likely due to their distinct pharmacokinetic profiles.

Navigating the Desert of Constipation

Constipation can feel like navigating a desert of discomfort. This research delves into the complexities of laxative action, providing valuable insights into the mechanisms by which these drugs work. Understanding these mechanisms can help us choose the most appropriate laxative for our individual needs.

Dr.Camel's Conclusion

This study provides a comparative analysis of the laxative effects of sennosides A+B and bisacodyl. The research highlights the distinct mechanisms of action and duration of action associated with these two commonly used laxatives.

Date :
  1. Date Completed 1989-09-21
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

2762373

DOI: Digital Object Identifier

10.1159/000138551

Related Literature

Article Analysis
・Effects of bisacodyl
SNS
PICO Info
in preparation
Languages

English

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