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Polyamines release the let-7b-mediated suppression of initiation codon recognition during the protein synthesis of EXT2.

Author: AkaseTomoko, AsakuraKiryu, FurihataTomomi, HigashiKyohei, IbukiAi, IgarashiKazuei, ImamuraMasataka, KashiwagiKeiko, LinhardtRobert J, MaegawaJiro, NishimuraKazuhiro, SatakeToshihiko, TeruiYusuke, ToidaToshihiko, YamaguchiKatsutoshi, YasumuraKazunori

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Polyamine levels are correlated with the expression level of heparan sulfate (HS) in human skin. This study found that the EXT1 and EXT2 enzymes, initiating HS biosynthesis, were stimulated at the translational level by polyamines. Let-7b, a member of the let-7 microRNA family, suppresses initiation codon recognition by 43S preinitiation complex during EXT2 translation. These findings provide new insights into the HS biosynthesis related to miRNA and polyamines.
Paper Details　
Original Abstract of the Article :
Proteoglycans (PGs), a family of glycosaminoglycan (GAG)-protein glycoconjugates, contribute to animal physiology through interactions between their glycan chains and growth factors, chemokines and adhesion molecules. However, it remains unclear how GAG structures are changed during the aging proces...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030709/

データ提供：米国国立医学図書館（NLM）

Unraveling the Role of Polyamines in Heparan Sulfate Biosynthesis

The intricate dance of cellular processes is a fascinating area of scientific exploration. This research focuses on the role of polyamines in heparan sulfate (HS) biosynthesis, investigating their impact on the expression of EXT1 and EXT2 enzymes, key players in HS production. The study reveals that polyamines stimulate EXT1 and EXT2 translation, highlighting their crucial role in regulating HS biosynthesis. Furthermore, the study sheds light on the regulatory mechanisms of let-7b microRNA, which suppresses initiation codon recognition during EXT2 translation. The findings provide novel insights into the regulation of HS biosynthesis, linking miRNA and polyamines to this essential process.

The Regulatory Dance of Polyamines and MicroRNAs

The study's findings demonstrate a complex interplay between polyamines and microRNAs in regulating HS biosynthesis. Polyamines stimulate EXT1 and EXT2 translation, while let-7b microRNA suppresses initiation codon recognition during EXT2 translation. This intricate regulatory dance highlights the complexity of cellular processes and the importance of understanding these interactions for developing targeted therapies.

Understanding the Complexities of Heparan Sulfate Biosynthesis

The research emphasizes the vital role of heparan sulfate in various biological processes, making it a crucial target for understanding cellular function and developing therapies. By revealing the regulatory mechanisms of polyamines and microRNAs in HS biosynthesis, this study provides valuable insights into the molecular intricacies of cellular processes and their potential for therapeutic interventions.

Dr. Camel's Conclusion

Just as a camel's hump stores essential nutrients for survival in the desert, cells rely on heparan sulfate to support various essential functions. This research uncovers the intricate regulatory mechanisms governing heparan sulfate biosynthesis, shedding light on the complex symphony of cellular processes.

Date :
  1. Date Completed 2018-06-04
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

27650265

DOI: Digital Object Identifier

PMC5030709

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English

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