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Safety and immunogenicity of a live attenuated pentavalent rotavirus vaccine in HIV-exposed infants with or without HIV infection in Africa.

Author: Bwakura-DangarembiziMutsa, HilleDarcy, KaplanSusan S, LawrenceJody, LevinMyron J, LindseyJane C, McNealMonica M, MpabalwaniEvans M, NelsonMargaret, OgwuAnthony, SatoPaul, SchimanaWerner, SiberryGeorge, WeinbergAdriana, WeinbergGeoffrey A

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

This abstract discusses the limited prospective data on the safety and immunogenicity of live rotavirus vaccines in HIV-infected (HIV+) and HIV-exposed but uninfected (HEU) infants.
Paper Details　
Original Abstract of the Article :
Although many HIV-infected (HIV+) and HIV-exposed but uninfected (HEU) infants have received live rotavirus vaccines since the WHO recommended universal administration of these vaccines to infants, there has been limited prospective information on their safety and immunogenicity in either group of i...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://pubmed.ncbi.nlm.nih.gov/27662551

データ提供：米国国立医学図書館（NLM）

Navigating the Desert of HIV and Rotavirus: A Vaccine's Journey

The desert of HIV is a complex and unforgiving landscape, and the health of infants exposed to the virus is a constant concern. This study focuses on the safety and effectiveness of a live attenuated pentavalent rotavirus vaccine in infants exposed to HIV, both those infected and uninfected. The researchers aimed to gather more information about the vaccine's impact on these vulnerable infants, as there has been limited research in this area.

A Safe Haven in the Desert of HIV

The findings show that the rotavirus vaccine was safe and immunogenic (meaning it triggered an immune response) in both HIV-infected and HIV-exposed but uninfected infants. This is positive news as it suggests the vaccine can be safely administered to these infants, potentially providing protection against rotavirus infection.

Hope for a Healthier Future

This study provides a glimmer of hope in the desert of HIV, demonstrating the safety and immunogenicity of a crucial vaccine in a vulnerable population. The findings pave the way for wider access to this vaccine for infants exposed to HIV, potentially improving their health outcomes and contributing to a healthier future.

Dr.Camel's Conclusion

This study is like a beacon of hope in the vast desert of HIV, demonstrating the safety and effectiveness of a vital vaccine for infants exposed to the virus. The findings emphasize the importance of continued research in this challenging landscape, as we strive to find solutions that improve the health and well-being of vulnerable populations.

Date :
  1. Date Completed 2017-12-20
  2. Date Revised 2020-03-06
Further Info :

Pubmed ID

27662551

DOI: Digital Object Identifier

NIHMS819561

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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