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Tropane alkaloids as substrates and inhibitors of human organic cation transporters of the SLC22 (OCT) and the SLC47 (MATE) families.

Author: BrockmöllerJürgen, ChenJiayin, ChenXijing, KönigJörg, SeitzTina, TzvetkovMladen V

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the role of organic cation transporters (OCTs) and multidrug and toxin extrusion proteins (MATEs) in the renal and extra-renal excretion of tropane alkaloids and their derivatives. OCT1, OCT2, and MATEs were identified as potential mediators of excretion, with strong transport of ipratropium and trospium. The study highlights the potential for drug-drug interactions involving these transporters, which could affect the elimination of drugs with narrow therapeutic ranges.
Paper Details　
Original Abstract of the Article :
Tropane alkaloids and their derivatives are anticholinergic drugs with narrow therapeutic range. Here we characterize the organic cation transporters from the SLC22 (OCT1, OCT2, and OCT3) and the SLC47 families (MATE1 and MATE2-K) as potential mediators of the renal and extra-renal excretion, the tw...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/27676604

データ提供：米国国立医学図書館（NLM）

Tropane Alkaloids: Navigating the Desert of Drug Interactions

Imagine a desert caravan carrying precious cargo, each ingredient needing careful handling to avoid unexpected reactions. Tropane alkaloids are like those valuable ingredients, used in medications but requiring careful management due to their potential for drug interactions. This research explored how these alkaloids interact with specific transporters in the body, influencing their absorption, distribution, and elimination. The study found that certain transporters play a critical role in handling these alkaloids, suggesting that drug-drug interactions could occur with other medications.

Transporters: Key Navigators in the Desert of Drug Interactions

The study found that certain transporters play a critical role in handling tropane alkaloids, suggesting that drug-drug interactions could occur with other medications. This highlights the importance of considering these interactions when prescribing medications containing tropane alkaloids.

Careful Management is Crucial

The research emphasizes the need for careful management of medications containing tropane alkaloids to minimize the risk of drug-drug interactions. This includes thorough patient history and monitoring for potential side effects.

Dr.Camel's Conclusion

Tropane alkaloids are like precious ingredients in a desert caravan, needing careful handling to avoid unwanted reactions. This research explored how specific transporters, like skilled caravan guides, manage these alkaloids. The study highlights the importance of understanding these interactions, ensuring a safe and successful journey through the desert of drug interactions.

Date :
  1. Date Completed 2017-07-10
  2. Date Revised 2018-02-08
Further Info :

Pubmed ID

27676604

DOI: Digital Object Identifier

/j/bchm.just-accepted/hsz-2016-0236/hsz-2016-0236.xml

Related Literature

Article Analysis
・Effects of trospium
SNS
PICO Info
in preparation
Languages

English

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