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The Role of Panobinostat Plus Bortezomib and Dexamethasone in Treating Relapsed or Relapsed and Refractory Multiple Myeloma: A European Perspective.
Author: EinseleHermann, MoreauPhilippe, San-MiguelJesus F
Original Abstract of the Article :
Panobinostat is an oral pan-histone deacetylase inhibitor developed by Novartis. Panobinostat acts via epigenetic modification and inhibition of the aggresome pathway. In August 2015, the European Commission authorized panobinostat for use in combination with bortezomib and dexamethasone for the tre...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083773/
データ提供:米国国立医学図書館(NLM)
Panobinostat: A Promising Oasis in the Desert of Multiple Myeloma
Multiple myeloma, a complex and often aggressive cancer, presents a formidable challenge for clinicians. This study explores the potential of panobinostat, a histone deacetylase inhibitor, in treating relapsed or refractory multiple myeloma. The researchers, like intrepid desert explorers, navigate the complexities of this disease, seeking to identify new therapeutic options.
A Novel Approach: Panobinostat Offers a Refreshing Perspective
This study illuminates the potential of panobinostat as a valuable tool in treating relapsed or refractory multiple myeloma. The research demonstrates that panobinostat, in combination with bortezomib and dexamethasone, can significantly improve progression-free survival in this patient population. This is like discovering a hidden oasis in the heart of a vast desert, offering a much-needed respite from the harsh realities of this disease.
Navigating the Challenges: Safety and Effectiveness
The study carefully explores the safety and efficacy of panobinostat, addressing concerns about potential toxicity and outlining strategies for mitigating risks. This meticulous approach is crucial for ensuring the long-term well-being of patients undergoing this treatment regimen. It's akin to navigating a treacherous desert terrain, requiring a deep understanding of the landscape and the risks involved.
Dr. Camel's Conclusion
This research offers a valuable roadmap for navigating the complex world of multiple myeloma treatment. It highlights the potential of panobinostat as a promising therapeutic option, particularly for patients with relapsed or refractory disease. The study emphasizes the importance of carefully evaluating safety and efficacy, ensuring that patients receive optimal care and benefit from this innovative treatment approach.
Date :
- Date Completed 2017-08-18
- Date Revised 2023-11-04
Further Info :
Related Literature
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