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Genetic Determinants of Clozapine-Induced Metabolic Side Effects.

Author: ChoiYun-Hee, KimRichard B, NormanRoss, SchwarzUte I, VasudevKamini

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A high prevalence of metabolic side effects was found in patients on clozapine.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: Atypical antipychotics are linked to a higher incidence of metabolic side effects, including weight gain, dyslipidemia, and diabetes. In this study, we examined the prevalence and potential genetic predictors of metabolic side effects in 60 adult patients on clozapine. METHOD: Genetic va...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298525/

データ提供：米国国立医学図書館（NLM）

Genetic Factors in Clozapine-Induced Metabolic Side Effects

This research investigates the genetic factors that may contribute to the development of metabolic side effects in patients taking clozapine, an atypical antipsychotic medication. The authors, like skilled geneticists unraveling the intricate code of life, explore the potential role of genetic variations in influencing the risk of metabolic side effects in individuals taking clozapine.

Identifying Genetic Predictors of Metabolic Side Effects

This research identifies specific genetic markers associated with an increased risk of metabolic side effects in patients taking clozapine. The authors found that variations in genes involved in clozapine metabolism, clearance, and response, as well as genes related to leptin and leptin receptor signaling, were linked to an increased risk of weight gain and metabolic syndrome.

Personalized Approaches to Medication Management

This research highlights the importance of personalized approaches to medication management, taking into account individual genetic factors. The findings suggest that by identifying individuals who are genetically predisposed to metabolic side effects, clinicians may be able to tailor treatment plans to minimize these risks. Imagine a vast desert with different oases offering unique resources. Each individual's genetic makeup is like their own oasis, with varying levels of susceptibility to certain medications.

Dr. Camel's Conclusion

This research underscores the importance of considering genetics when prescribing clozapine. By identifying individuals who are genetically predisposed to metabolic side effects, clinicians can tailor treatment plans to minimize these risks and improve patient outcomes.
Date :
  1. Date Completed 2017-12-08
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

27681143

DOI: Digital Object Identifier

PMC5298525

Related Literature

Article Analysis
・Side Effects of clozapine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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