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Methazolamide improves neurological behavior by inhibition of neuron apoptosis in subarachnoid hemorrhage mice.

Author: ChenQianxue, DengGang, GaoLing, GaoYufeng, LiMingchang, MaiHaojian, WangJian, WangWei, WangXin, WangYuefei, ZhangXinmu, ZhouShuanhu

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Methazolamide, a carbonic anhydrase inhibitor, has neuroprotective effects in a subarachnoid hemorrhage (SAH) animal model and in blood-induced primary cortical neuron (PCNs) cellular model of SAH. It accelerates recovery of neurological damage, relieves cerebral edema, and improves cognitive function, but does not protect against mortality, cerebral blood flow fluctuations, SAH grade, or cerebral vasospasm.
Paper Details　
Original Abstract of the Article :
Subarachnoid hemorrhage (SAH) results in significant nerve dysfunction, such as hemiplegia, mood disorders, cognitive and memory impairment. Currently, no clear measures can reduce brain nerve damage. The study of brain nerve protection after SAH is of great significance. We aim to evaluate the prot...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059745/

データ提供：米国国立医学図書館（NLM）

Methazolamide for Subarachnoid Hemorrhage

Subarachnoid hemorrhage (SAH) is a devastating neurological event that can lead to significant nerve damage. Currently, there are limited treatment options to mitigate the devastating effects of SAH. This study investigates the protective effects of methazolamide in a mouse model of SAH, exploring its potential as a novel therapeutic agent. The researchers demonstrate methazolamide's ability to accelerate neurological recovery, alleviate cerebral edema, and improve cognitive function in mice experiencing SAH.

Potential for Neuroprotection

This research offers a glimmer of hope in the vast desert of SAH treatment. The findings suggest that methazolamide, a carbonic anhydrase inhibitor, may provide neuroprotective benefits by inhibiting neuron apoptosis. These promising results warrant further investigation to determine the full potential of methazolamide in treating SAH.

Navigating Neurological Challenges

This study underscores the importance of exploring innovative therapeutic strategies for managing SAH. The potential of methazolamide to mitigate the neurotoxic effects of SAH presents a new avenue for research and development, potentially leading to improved treatment options for this debilitating condition.

Dr.Camel's Conclusion

This research is a compelling reminder that even in the face of seemingly insurmountable challenges, like the vastness of a desert, innovative solutions can emerge. The potential of methazolamide to provide neuroprotection in SAH is a beacon of hope in the ongoing quest for effective treatments. By continuing to explore the complexities of brain injury and neurodegenerative diseases, we can bring light and life to those navigating the challenging terrain of these conditions.

Date :
  1. Date Completed 2018-04-25
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

27731352

DOI: Digital Object Identifier

PMC5059745

Related Literature

Article Analysis
・Effects of methazolamide
SNS
PICO Info
in preparation
Languages

English

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