Effects of Longterm Treatment with Bosentan and Iloprost on Nailfold Absolute Capillary Number, Fingertip Blood Perfusion, and Clinical Status in Systemic Sclerosis.

Author: CutoloMaurizio, PaolinoSabrina, PizzorniCarmen, RuaroBarbara, SmithVanessa, SulliAlberto, TrombettaAmelia Chiara

Paper Details 
Original Abstract of the Article :
Label="OBJECTIVE">To quantify in patients with systemic sclerosis (SSc) the absolute nailfold capillary number/mm (the absolute number of capillaries, observable in the first row, in 1 mm per field) and fingertip blood perfusion (FBP) during longterm therapy with the endothelin receptor antagonist b...See full text at original site
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引用元:
https://doi.org/10.3899/jrheum.160592

データ提供:米国国立医学図書館(NLM)

Long-Term Treatment with Bosentan and Iloprost in Systemic Sclerosis

This research investigates the effects of long-term treatment with bosentan and iloprost, two medications used to manage systemic sclerosis (SSc), on capillary density and blood flow. The study examined the impact of these medications on nailfold capillary number and fingertip blood perfusion in patients with SSc. The researchers sought to understand the long-term effects of these medications on microvascular function in SSc.

Bosentan and Iloprost: Impact on Microvascular Function in SSc

The study found that long-term treatment with bosentan and iloprost had a positive impact on nailfold capillary number and fingertip blood perfusion in patients with SSc. These findings suggest that these medications may improve microvascular function in SSc, potentially mitigating the disease's debilitating effects. It's like finding a hidden oasis in the desert of SSc, offering a lifeline of improved blood flow and microvascular health.

Potential Benefits for SSc Management

This research highlights the potential benefits of bosentan and iloprost in managing SSc. By improving microvascular function, these medications may alleviate symptoms, improve quality of life, and potentially slow disease progression. Further research is needed to fully understand the long-term benefits and optimal treatment strategies for SSc.

Dr. Camel's Conclusion

This study offers promising insights into the potential of bosentan and iloprost in managing SSc. By improving microvascular function, these medications may offer a beacon of hope for patients battling this complex and debilitating disease. As we journey through the desert of SSc research, we must continue to explore new therapeutic options and strategies to improve the lives of those affected by this condition.

Date :
  1. Date Completed 2017-12-07
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

27744392

DOI: Digital Object Identifier

10.3899/jrheum.160592

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English

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