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Electrospun poly-l-lactide scaffold for the controlled and targeted delivery of a synthetically obtained Diclofenac prodrug to treat actinic keratosis.

Author: BochicchioBrigida, HindererSvenja, PepeAntonietta, PiccirilloGermano, Schenke-LaylandKatja

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study develops and characterizes an electrospun polylactic acid (PLA) scaffold loaded with a synthetic diclofenac (DCF) prodrug for the treatment of Actinic Keratosis (AKs). The prodrug was successfully synthesized by binding DCF to a glycine residue via solid phase peptide synthesis (SPPS) and incorporated into an electrospun PLA scaffold. The drug encapsulation was verified using multiphoton microscopy (MPM) and its scaffold release was spectrophotometrically monitored and confirmed with MPM. The scaffold was further characterized with scanning electron microscopy (SEM), tensile testing, and contact angle measurements. Its biocompatibility was verified by performing a cell proliferation assay and compared to PLA scaffolds containing the same amount of DCF sodium salt (DCFONa). The effect of the electrospun scaffolds on human dermal fibroblasts (HDFs) morphology and metabolism was investigated by combining MPM with fluorescence lifetime imaging microscopy (FLIM). The obtained results suggest that the obtained scaffold could be suitable for the controlled and targeted delivery of the synthesized prodrug for the treatment of AKs.
Paper Details　
Original Abstract of the Article :
Actinic Keratosis' (AKs) are small skin lesions that are related to a prolonged sun-damage, which can develop into invasive squamous cell carcinoma (SCC) when left untreated. Effective, specific and well tolerable therapies to cure AKs are still of great interest. Diclofenac (DCF) is the current gol...See full text at original site
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引用元：
https://doi.org/10.1016/j.actbio.2016.11.002

データ提供：米国国立医学図書館（NLM）

Electrospun Scaffolds: A New Frontier for Treating Actinic Keratosis

Actinic keratosis (AK) is a common skin condition, often caused by prolonged sun exposure, that can progress into invasive squamous cell carcinoma (SCC) if left untreated. This study explores a novel approach to treating AK using electrospun polylactic acid (PLA) scaffolds loaded with a synthetic diclofenac prodrug. Imagine a camel creating a shelter in the desert, offering protection and healing. Researchers in this study developed a scaffold that not only provides controlled and targeted delivery of the prodrug but also possesses excellent biocompatibility. The study found that the scaffold effectively released the prodrug over time, demonstrating its potential for treating AK. This approach could offer a safe and effective alternative to traditional treatments, potentially reducing the risk of SCC development.

Scaffolding Hope: A Desert Oasis for Actinic Keratosis

The study's findings suggest that electrospun PLA scaffolds loaded with a synthetic diclofenac prodrug could be a promising therapeutic option for treating AK. The scaffold's controlled and targeted delivery mechanism combined with its biocompatibility offers a potential solution for AK management. The study's results, like a refreshing oasis in the desert, bring new hope for patients seeking effective treatment for AK.

A Camel's Perspective on Skin Health: Protecting Your Oasis

This research highlights the potential of innovative techniques in treating skin conditions. The development of electrospun PLA scaffolds with controlled drug delivery offers a promising approach to managing AK, potentially preventing its progression to SCC. Just as a camel protects itself from the harsh desert sun, it's essential to protect our skin from harmful UV radiation. Remember, regular sunscreen application and seeking shade during peak sun hours are crucial for maintaining healthy skin.

Dr. Camel's Conclusion

Electrospun PLA scaffolds loaded with a synthetic diclofenac prodrug offer a promising approach to treating AK, a common skin condition. This innovative approach, like a camel finding shelter in the desert, provides a potential solution for AK management and could potentially prevent its progression to SCC. Remember, safeguarding our skin is essential for overall health, just as a camel relies on its adaptive strategies to survive in the harsh desert.

Date :
  1. Date Completed 2017-10-19
  2. Date Revised 2018-02-21
Further Info :

Pubmed ID

27816622

DOI: Digital Object Identifier

10.1016/j.actbio.2016.11.002

SNS
PICO Info
in preparation
Languages

English

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