Supratherapeutic dose evaluation and effect of lesinurad on cardiac repolarization: a thorough QT/QTc study.

Author: GillenMichael, HarmonErin, KerrBradley, LeeCaroline A, NguyenMai, ShenZancong, TieuKathy, WilsonDavid M

Paper Details 
Original Abstract of the Article :
Lesinurad is a selective uric acid reabsorption inhibitor approved in the United States and Europe for treatment of gout in combination with a xanthine oxidase inhibitor. A maximum tolerated dose study was conducted to determine the lesinurad supratherapeutic dose, followed by a thorough QTc study t...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096775/

データ提供:米国国立医学図書館(NLM)

Lesinurad: A New Approach to Gout Management

The world of [rheumatology] is constantly seeking new and effective treatments for [gout], a painful inflammatory condition. This study investigates the effects of [lesinurad], a [selective uric acid reabsorption inhibitor], on [cardiac repolarization]. It's like exploring a desert where a hidden oasis may hold the key to a cure; we need to carefully evaluate the potential benefits and risks of new treatments.

Lesinurad's Impact on Cardiac Repolarization

The researchers conducted a [thorough QTc study] to assess the impact of [lesinurad] on [cardiac repolarization]. This is like carefully examining the terrain of the desert before embarking on a journey; we need to understand the potential consequences of new treatments.

Managing Gout While Protecting the Heart

This research provides valuable insights into the [cardiac safety] of [lesinurad], a promising new treatment for [gout]. It's like finding a path through the desert that avoids dangerous sandstorms; we need to choose treatments that are both effective and safe for our hearts.

Dr.Camel's Conclusion

This study is a testament to the ongoing efforts to find safer and more effective treatments for [gout]. It's like finding a hidden oasis in the desert of medical research; every step forward brings us closer to a healthier future for patients suffering from this painful condition.

Date :
  1. Date Completed 2017-05-17
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

27826183

DOI: Digital Object Identifier

PMC5096775

Related Literature

Article Analysis
SNS
PICO Info
in preparation
Languages

English

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