Adverse events and treatment discontinuations of antimuscarinics for the treatment of overactive bladder in older adults: A systematic review and meta-analysis.

Author: KebodeauxClark D, StrangesPaul M, TeshomeBesu F, VouriScott Martin

Paper Details 
Original Abstract of the Article :
Antimuscarinics should be used with caution in older adults with overactive bladder (OAB) due to anticholinergic adverse events (AEs). Systematic reviews and meta-analyses (SRMAs) have analyzed safety-related outcomes but have not specified risk in the elderly, the population at highest risk for AEs...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://pubmed.ncbi.nlm.nih.gov/27889591

データ提供:米国国立医学図書館(NLM)

Antimuscarinics for Overactive Bladder: A Cautionary Note for Older Adults

Geriatrics is a field that focuses on the unique health needs of older adults. This study examines the safety of antimuscarinics, medications used to treat overactive bladder (OAB), in older adults. The researchers conducted a systematic review and meta-analysis to evaluate the frequency of adverse events and treatment discontinuations associated with antimuscarinics in this population.

Potential Risks: Antimuscarinics in Older Adults

The study found that older adults taking antimuscarinics for OAB were more likely to experience adverse events, such as dry mouth, constipation, and cognitive impairment, compared to younger adults. These side effects were also a common reason for discontinuing treatment. This highlights the need for careful consideration of the risks and benefits of antimuscarinics in older adults.

Managing Overactive Bladder: A Personalized Approach

This study underscores the importance of individualizing treatment decisions for OAB, particularly in older adults. While antimuscarinics can be effective for managing symptoms, it's crucial to weigh the potential benefits against the risks, especially in individuals who may be more susceptible to side effects. Non-pharmacological interventions, such as bladder training and lifestyle modifications, may also be helpful for managing OAB symptoms.

Dr.Camel's Conclusion

Just like a camel adapting to the harsh desert environment, older adults require careful consideration when it comes to medications. This study serves as a reminder that antimuscarinics, while effective for treating overactive bladder, can pose risks, especially for older adults. A personalized approach, considering both the potential benefits and risks, is crucial for optimal care.

Date :
  1. Date Completed 2017-07-05
  2. Date Revised 2019-10-08
Further Info :

Pubmed ID

27889591

DOI: Digital Object Identifier

NIHMS832536

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.