Phase 1/2 study of pacritinib, a next generation JAK2/FLT3 inhibitor, in myelofibrosis or other myeloid malignancies.

Author: Al-FayoumiSuliman, DeegH Joachim, GranstonTanya, OdenikeOlatoyosi, SingerJack W, VerstovsekSrdan

Paper Details 
Original Abstract of the Article :
Pacritinib (SB1518) is a highly selective kinase inhibitor with specificity for JAK2, FLT3, IRAK1, and CFS1R. This multicenter phase 1/2 study evaluated the maximum tolerated dose (MTD), safety, and clinical activity of pacritinib in patients with myelofibrosis (MF) and other advanced myeloid malign...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146859/

データ提供:米国国立医学図書館(NLM)

Pacritinib: A New Oasis in the Desert of Myeloid Malignancies

The world of cancer research, much like a vast and unforgiving desert, presents numerous challenges. This phase 1/2 study delves into the potential of pacritinib, a novel kinase inhibitor, as a treatment for myelofibrosis and other advanced myeloid malignancies. The researchers, much like explorers searching for a hidden oasis, sought to understand the safety and efficacy of this promising drug.

Pacritinib: A Promising New Weapon in the Fight Against Myeloid Malignancies

The study found that pacritinib demonstrated a favorable safety profile and exhibited encouraging clinical activity in patients with myelofibrosis and other advanced myeloid malignancies. The researchers' findings, like a cool spring emerging from the heart of the desert, offer hope for a more effective treatment option for these challenging diseases.

Navigating the Desert of Cancer Treatment

This study highlights the importance of continued research and innovation in the fight against cancer. The researchers' journey, much like a camel caravan enduring the hardships of the desert, underscores the commitment to finding new and effective therapies for patients facing these life-threatening diseases.

Dr.Camel's Conclusion

This study offers a glimmer of hope in the fight against myelofibrosis and other advanced myeloid malignancies. The researchers' findings, like a beacon illuminating a path through the desert, showcase the potential of pacritinib as a promising new treatment option for these challenging diseases. While further research is needed, this study serves as a crucial step towards a future where these cancers are no longer a death sentence.

Date :
  1. Date Completed 2017-12-01
  2. Date Revised 2022-03-17
Further Info :

Pubmed ID

27931243

DOI: Digital Object Identifier

PMC5146859

Related Literature

SNS
PICO Info
in preparation
Languages

English

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