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Effects of different combinations of nanocrystallization technologies on avanafil nanoparticles: in vitro, in vivo and stability evaluation.
Author: GhorabMahmoud Mohammed, IbrahimHowida Kamal, SolimanKareem AbuBakr
Original Abstract of the Article :
The study investigated the effects of different combined top-down and bottom-up nanocrystallization technologies on particle size and solid state of avanafil nanoparticles. Combined antisolvent precipitation-ultrasonication (sonoprecipitation) technique was adopted to prepare 18 formulas according t...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
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引用元:
https://doi.org/10.1016/j.ijpharm.2016.12.012
データ提供:米国国立医学図書館(NLM)
Nanotechnology Takes on Avanafil
The quest for more effective drug delivery systems is a constant challenge, much like a camel striving to cross a scorching desert! This study focuses on avanafil, a medication used for erectile dysfunction, and explores innovative nanocrystallization techniques to improve its effectiveness. The researchers creatively combined top-down and bottom-up approaches to manipulate the size and structure of avanafil nanoparticles. They experimented with various stabilizers and cryoprotectants, akin to a skilled desert nomad carefully selecting the right tools for their journey. This research provides a fascinating glimpse into the potential of nanotechnology in drug delivery, showcasing the possibility of enhancing both solubility and bioavailability of medications.
Nanotechnology: Boosting Avanafil's Performance
The study demonstrates that nanocrystallization technologies can significantly improve the solubility and bioavailability of avanafil. This means that the drug can be absorbed more efficiently by the body, leading to better therapeutic outcomes. The researchers found that certain combinations of nanocrystallization methods and stabilizers led to a remarkable increase in solubility and in vitro dissolution, a testament to the ingenuity of this approach. This research suggests that nanotechnology can play a crucial role in optimizing drug delivery, improving patient outcomes.
Nanotechnology: A New Frontier in Drug Delivery
This study is a testament to the transformative power of nanotechnology in the pharmaceutical industry. Imagine a camel carrying a precious cargo across a vast desert, navigating through obstacles and maximizing efficiency. This is precisely what nanotechnology offers, allowing us to transport drugs more effectively, enhancing their absorption and impact. This research opens up exciting possibilities for optimizing drug delivery systems and improving patient care.
Dr.Camel's Conclusion
This study is a beacon of hope in the desert of pharmaceutical research, demonstrating the potential of nanotechnology to revolutionize drug delivery. By manipulating the size and structure of drug particles, we can unlock new levels of effectiveness and efficiency, improving patient outcomes and transforming the landscape of healthcare. It’s a testament to the boundless possibilities of human ingenuity and the enduring quest to improve our well-being.
Date :
- Date Completed 2017-06-13
- Date Revised 2017-06-27
Further Info :
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English
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