Paper Details

  1. Home
  2. Paper Details

Effects of exemestane and letrozole therapy on plasma concentrations of estrogens in a randomized trial of postmenopausal women with breast cancer.

Author: DestaZereunesay, FlockhartDavid A, HayesDaniel F, HenryN Lynn, HertzDaniel, LiLang, NguyenAnne T, RaeJames M, RobargeJason D, SkaarTodd C, StearnsVered, StornioloAnna M

Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Aromatase inhibitors (AIs) are medications used to treat breast cancer by blocking the production of estrogen. This study investigated the levels of estrogen in the blood of breast cancer patients who were taking AIs. The study found that there was significant variability in estrogen levels among patients, suggesting that individual responses to AI therapy may vary.
Paper Details　
Original Abstract of the Article :
Inter-individual differences in estrogen concentrations during treatment with aromatase inhibitors (AIs) may contribute to therapeutic response and toxicity. The aim of this study was to determine plasma concentrations of estradiol (E2), estrone (E1), and estrone sulfate (E1S) in a large cohort of A...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/27943008

データ提供：米国国立医学図書館（NLM）

Aromatase Inhibitors: A Closer Look at Estrogen Levels in Breast Cancer Treatment

This study delves into the complex landscape of breast cancer treatment, specifically focusing on the use of aromatase inhibitors (AIs). AIs are a class of drugs that block the production of estrogen, a hormone that can fuel the growth of certain types of breast cancer. This study investigates the impact of AI treatment on plasma concentrations of estrogen in postmenopausal women with breast cancer.

Estrogen Levels During Aromatase Inhibitor Treatment

The research examines the variability in estrogen levels among patients undergoing AI treatment. The study found significant differences in the concentrations of estradiol, estrone, and estrone sulfate among patients receiving either exemestane or letrozole, two commonly used AIs. These findings highlight the importance of monitoring estrogen levels during AI treatment to ensure optimal therapeutic response and minimize potential side effects.

Personalized Treatment Strategies for Breast Cancer

This study emphasizes the need for personalized treatment approaches in breast cancer management. Monitoring estrogen levels during AI treatment can help guide individualized treatment strategies, optimizing drug dosage and duration to maximize effectiveness and minimize side effects. The study's findings contribute to a more tailored and patient-centered approach to breast cancer care.

Dr.Camel's Conclusion

This study underscores the importance of understanding the nuances of hormone-based therapies in breast cancer treatment. By monitoring estrogen levels during AI treatment, healthcare professionals can personalize treatment plans to maximize efficacy and minimize side effects. This research contributes to a more precise and patient-centered approach to breast cancer management.

Date :
  1. Date Completed 2017-12-07
  2. Date Revised 2023-11-04
Further Info :

Pubmed ID

27943008

DOI: Digital Object Identifier

NIHMS859419

Related Literature

Article Analysis
・Effects of exemestane
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.