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Drug-Induced Liver Injury.

Author: CollinsRachel E, Collins-YoderAngela, HamiltonLeslie A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Drug-induced liver injury (DILI) can be caused by a variety of medications, including antibiotics, antiepileptic drugs, statins, and others. It is important to recognize the signs and symptoms of DILI, as it can be serious and potentially life-threatening. DILI can be broadly classified as idiosyncratic, meaning it is unpredictable and often due to an individual's unique sensitivity to a drug, or intrinsic, meaning it is predictable and directly related to the dose of the drug. The primary treatment for IDILI is to stop the drug immediately. For acetaminophen overdose, activated charcoal and N-acetylcysteine can be used to protect the liver.
Paper Details　
Original Abstract of the Article :
Drug-induced liver injury (DILI) can result from both idiosyncratic and intrinsic mechanisms. This article discusses the clinical impact of DILI from a broad range of medications as well as herbal and dietary supplements. Risk factors for idiosyncratic DILI (IDILI) are the result of multiple host, e...See full text at original site
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引用元：
https://doi.org/10.4037/aacnacc2016953

データ提供：米国国立医学図書館（NLM）

Drug-Induced Liver Injury: A Complex Desert Landscape

Drug-induced liver injury (DILI), a serious complication that can arise from medication use, is like a treacherous desert landscape. This study, like a seasoned explorer, provides a comprehensive overview of DILI, covering both idiosyncratic and intrinsic mechanisms of liver damage. The authors discuss the clinical impact of DILI across a wide range of medications, including herbal and dietary supplements, highlighting the importance of understanding the potential risks associated with medication use. The study also delves into the risk factors for idiosyncratic DILI (IDILI), a complex interplay of host, environmental, and compound factors.

Navigating the Desert of Medication Safety

The study identifies a range of medications commonly associated with IDILI, including antibiotics, antiepileptic drugs, statins, and proton pump inhibitors. This information is crucial for healthcare providers to make informed decisions about medication selection and monitoring, minimizing the risk of DILI. The study also underscores the importance of patient education and awareness, empowering individuals to actively participate in their own healthcare decisions and report any potential side effects.

Protecting Our Liver Oasis

This research provides a crucial roadmap for navigating the desert of medication safety. By understanding the complex factors that contribute to DILI, we can make informed decisions about medication use and minimize the risk of this serious complication. This knowledge is essential for protecting our liver, a vital organ responsible for detoxifying our bodies and maintaining our overall health. This study serves as a reminder that even the most beneficial medications can have unintended consequences, highlighting the importance of careful monitoring and proactive prevention.

Dr. Camel's Conclusion

This study offers a comprehensive and insightful exploration of drug-induced liver injury (DILI). The authors provide a clear and informative overview of the complex factors that contribute to this serious complication, highlighting the importance of medication safety and patient education. This study serves as a reminder that even in the desert of medication use, we can find our way to safety and well-being by making informed decisions and staying vigilant about potential risks.

Date :
  1. Date Completed 2017-04-11
  2. Date Revised 2017-04-11
Further Info :

Pubmed ID

27959299

DOI: Digital Object Identifier

10.4037/aacnacc2016953

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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