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The effects of the DNA methyltranfserases inhibitor 5-Azacitidine on ageing, oxidative stress and DNA methylation of adipose derived stem cells.

Author: KornickaKatarzyna, MaryczKrzysztof, MarędziakMonika, NicpońJakub, TomaszewskiKrzysztof A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effect of the DNA methyltransferase (DNMT) inhibitor 5-Azacytidine (5-AZA) on the aged phenotype of mesenchymal stem cells (MSCs). The study found that 5-AZA reversed the aged phenotype of MSCs, increasing proliferation rate and reducing oxidative stress factors and DNA methylation status.
Paper Details　
Original Abstract of the Article :
Human adipose tissue is a great source of adult mesenchymal stem cells (MSCs) which are recognized from their ability to self-renew and differentiation into multiple lineages. MSCs have promised a vast therapeutic potential in treatment many diseases including tissue injury and immune disorders. How...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264131/

データ提供：米国国立医学図書館（NLM）

5-Azacitidine: A Potential Anti-Aging Agent for Adipose-Derived Stem Cells

Stem cells hold immense potential for regenerative medicine, but their therapeutic efficacy can decline with age. This study investigates the effects of 5-azacitidine, a DNA methyltransferase inhibitor, on the aging process of adipose-derived stem cells (MSCs). The researchers explored the potential of 5-azacitidine to reverse the age-related decline in MSC function, specifically addressing the accumulation of oxidative stress and changes in DNA methylation.

5-Azacitidine: Reversing the Aging Clock for Stem Cells

The study found that 5-azacitidine treatment reversed the age-related phenotype of MSCs, enhancing their proliferation rate and reducing oxidative stress. It also led to decreased DNA methylation status, suggesting that 5-azacitidine could rejuvenate aging MSCs and restore their regenerative potential. It's like finding a hidden spring in the desert of aging – 5-azacitidine could be a source of renewal for stem cells.

Rejuvenating Stem Cells: A Potential for Regenerative Medicine

The study's findings are exciting, as they suggest a potential for 5-azacitidine to improve the therapeutic efficacy of MSCs in regenerative medicine. However, further research is needed to fully understand the long-term effects of 5-azacitidine on MSC function and to evaluate its safety and effectiveness in clinical settings. This is an area of ongoing research, and the potential benefits for regenerative medicine are immense.

Dr. Camel's Conclusion

This study delves into the fascinating world of stem cell aging and explores the potential of 5-azacitidine to rejuvenate aging MSCs. The findings are promising, but further research is needed to fully understand the implications for regenerative medicine. This research is like a beacon of hope in the desert of aging, guiding us towards a future where stem cells can play an even greater role in restoring health and well-being.

Date :
  1. Date Completed 2017-07-31
  2. Date Revised 2022-03-10
Further Info :

Pubmed ID

27998022

DOI: Digital Object Identifier

PMC5264131

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SNS
PICO Info
in preparation
Languages

English

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