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Effects of Renal Function on Crizotinib Pharmacokinetics: Dose Recommendations for Patients with ALK-Positive Non-Small Cell Lung Cancer.

Author: BelloAkintunde, BoutrosTanya, BregaNicoletta M, JohnsonTheodore R, KirkovskyLeonid, O'GormanMelissa T, TanWeiwei, WangRong, YamazakiShinji

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study evaluated the pharmacokinetics of crizotinib, an anaplastic lymphoma kinase (ALK) inhibitor, in patients with renal impairment. The results suggest that crizotinib dosing adjustments are necessary for patients with mild, moderate, or severe renal impairment to optimize treatment efficacy and minimize potential adverse events.
Paper Details　
Original Abstract of the Article :
Crizotinib (250 mg twice daily) is the first anaplastic lymphoma kinase (ALK) inhibitor approved for treatment of ALK-positive non-small-cell lung cancer (NSCLC). The objectives of the current study were to evaluate the effects of mild, moderate, and severe renal impairment on crizotinib pharmacokin...See full text at original site
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引用元：
https://doi.org/10.1007/s40261-016-0490-z

データ提供：米国国立医学図書館（NLM）

Crizotinib and Kidney Function: A Balancing Act

Crizotinib is a targeted therapy used to treat ALK-positive non-small cell lung cancer (NSCLC). However, like many medications, crizotinib's effectiveness can be influenced by kidney function. This research aimed to evaluate the impact of impaired renal function on the pharmacokinetics of crizotinib, which refers to how the drug is absorbed, distributed, metabolized, and eliminated by the body. The researchers sought to develop dosing recommendations for NSCLC patients with impaired kidney function.

Adjusting the Dose: A Tailored Approach

The study revealed that crizotinib's pharmacokinetics were affected by varying degrees of renal impairment. This finding emphasized the importance of adjusting crizotinib dosing based on kidney function to optimize treatment effectiveness and safety. This is crucial because the results from this study suggest that patients with impaired kidney function might require adjustments in their crizotinib dosage to ensure the best possible outcomes.

Balancing Treatment and Safety

Crizotinib, like many other medications, needs to be carefully managed, especially in individuals with kidney problems. This study helps physicians make informed decisions about crizotinib dosing for patients with impaired renal function. Just like a camel adapting to the desert's conditions, individual patients may need unique adjustments to their treatment plan to maximize the benefits and minimize potential risks.

Dr. Camel's Conclusion

Imagine a caravan crossing a vast desert, encountering a shifting landscape. Just as the caravan adjusts its path to navigate changing terrain, crizotinib dosing needs to be adapted based on a patient's kidney function. This research underscores the importance of individualized care and a personalized approach to medication management, especially when dealing with complex conditions like cancer.

Date :
  1. Date Completed 2017-04-10
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

28035616

DOI: Digital Object Identifier

10.1007/s40261-016-0490-z

Related Literature

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・Effects of crizotinib
SNS
PICO Info
in preparation
Languages

English

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