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Analgesic Effects and Side Effects of Ephedra Herb Extract and Ephedrine Alkaloids-free Ephedra Herb Extract.

Author: KobayashiYoshinori

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study explores the potential role of transient receptor potential vanilloid 1 (TRPV1) activation in the pharmacological action of Ephedra Herb, a traditional Chinese medicine. Ephedra Herb extract (EHE) was found to activate TRPV1, contributing to its analgesic effects, while ephedrine, a component of EHE, did not exhibit this effect. Ephedrine alkaloids-free EHE (EFE) demonstrated similar analgesic effects without side effects, suggesting potential for its use in Kampo medicine.
Paper Details　
Original Abstract of the Article :
Ephedra Herb is classified "pungent, slightly bitter, and warm" in tastes and natures, and is used to provide warmth to the body, dispel coldness, remove dampness, and reduce pain. Similar herbs are "pungent and hot" chili peppers, "pungent and hot" evodia fruit," "pungent and warm" ginger, "pungent...See full text at original site
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引用元：
https://doi.org/10.1248/yakushi.16-00233-5

データ提供：米国国立医学図書館（NLM）

Ephedra Herb Extract: Analgesic Effects and Side Effects

Ephedra Herb has been used in traditional medicine for its various therapeutic properties, including pain relief. This study investigates the analgesic effects and side effects of Ephedra Herb extract (EHE) and an ephedrine alkaloid-free EHE (EFE). The researchers examined the effects of both extracts on TRPV1 activation, a pain receptor, and explored their analgesic efficacy and potential side effects in mice.

Ephedra Herb Extract: A Potential Analgesic with Cautions

The study found that EHE showed strong TRPV1 activation, while ephedrine itself did not. Both EHE and EFE demonstrated analgesic effects, suggesting the presence of active components other than ephedrine alkaloids. However, EFE did not exhibit side effects like loss of sleep and irregular heartbeat observed in mice treated with EHE. These findings suggest that EFE may be a safer alternative to EHE for pain relief.

Navigating the Desert of Pain: A Camel's Perspective

Pain can feel like a scorching desert sun, burning away at your comfort and well-being. Ephedra Herb has been used traditionally for pain relief, but its use should be approached cautiously due to potential side effects. This study reveals that EFE, a derivative of Ephedra Herb, may offer a safer option for pain management.

Dr.Camel's Conclusion

This study highlights the potential of Ephedra Herb extracts for pain relief. While EHE demonstrates analgesic effects, its potential side effects warrant caution. EFE, free from ephedrine alkaloids, appears to be a promising alternative for managing pain with reduced side effects.

Date :
  1. Date Completed 2017-05-05
  2. Date Revised 2017-10-16
Further Info :

Pubmed ID

28154330

DOI: Digital Object Identifier

10.1248/yakushi.16-00233-5

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PICO Info
in preparation
Languages

Japanese

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