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Contribution of both olfactory and systemic pathways for brain targeting of nimodipine-loaded lipo-pluronics micelles: in vitro characterization and in vivo biodistribution study after intranasal and intravenous delivery.

Author: BasaliousEmad B, RashedHassan M, ShammaRehab N

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Nimodipine, a drug used to treat subarachnoid hemorrhage, has poor oral bioavailability due to low solubility. This study developed a radiolabeled nimodipine-loaded lipid-polymer hybrid (LPM) formulation to improve drug delivery. The study found that the LPM formulation had a longer circulation time and targeted the brain tissue more effectively than nimodipine solution. This formulation also reduced drug accumulation in the heart, minimizing cardiovascular side effects. The LPM formulation shows promise for improving nasal and intravenous delivery of nimodipine.
Paper Details　
Original Abstract of the Article :
Nimodipine (NM) is the only FDA-approved drug for treating subarachnoid hemorrhage induced vasospasm. NM has poor oral bioavailability (5-13%) due to its low aqueous solubility, and extensive first pass metabolism. The objective of this study is to develop radiolabeled NM-loaded LPM and to test its ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241048/

データ提供：米国国立医学図書館（NLM）

Brain Targeting of Nimodipine: A New Path to Treating Vasospasm

Subarachnoid hemorrhage (SAH) is a serious medical condition that can lead to life-threatening complications, including vasospasm, a narrowing of blood vessels in the brain. This study explores a promising new approach to delivering nimodipine, a drug used to treat SAH-induced vasospasm, directly to the brain. It's like discovering a shortcut through the desert, allowing for a faster and more efficient journey to the destination.

A Novel Delivery System

The researchers developed a novel delivery system for nimodipine, using lipo-pluronics micelles (LPM) to enhance its solubility and bioavailability. This system has the potential to improve the delivery of nimodipine to the brain, reducing the frequency of administration and minimizing potential side effects. This is like finding a new type of camel that is better adapted to traversing the desert, allowing for faster travel and a smoother journey. The study also investigated the potential of intranasal administration, a non-invasive route that could offer a convenient alternative to intravenous delivery.

The Promise of Targeted Delivery

This research offers a promising new approach to treating SAH-induced vasospasm. By improving the delivery of nimodipine to the brain, the researchers aim to improve treatment outcomes and reduce the risk of complications. This is like utilizing a well-maintained road network to reach the destination safely and efficiently. The study highlights the importance of exploring innovative drug delivery systems to optimize therapeutic outcomes and enhance patient care.

Dr.Camel's Conclusion

This study explores a promising new approach to delivering nimodipine, a drug used to treat SAH-induced vasospasm, directly to the brain. The researchers utilized a novel delivery system using lipo-pluronics micelles (LPM) to enhance nimodipine's solubility and bioavailability. This research could lead to improved treatment outcomes and reduced side effects for patients with SAH-induced vasospasm. It's like discovering a new way to navigate the desert, offering a faster, safer, and more efficient journey to the destination.

Date :
  1. Date Completed 2017-02-23
  2. Date Revised 2021-07-09
Further Info :

Pubmed ID

28156162

DOI: Digital Object Identifier

PMC8241048

Related Literature

Article Analysis
・Side Effects of nimodipine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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