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Chronic and acute adenosine A<sub>2A</sub> receptor blockade prevents long-term episodic memory disruption caused by acute cannabinoid CB<sub>1</sub> receptor activation.

Author: BaqiYounis, BatalhaVânia L, CoelhoJoana E, FerreiraDiana G, LopesLuísa V, MouroFrancisco M, MüllerChrista E, RibeiroJoaquim A, SebastiãoAna M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Caffeine exacerbates cannabinoid CB1 receptor-induced memory deficits, but blocking adenosine A2A receptors can prevent these cognitive impairments. This study investigates the effects of chronic or acute blockade of A2A receptors on long-term episodic memory deficits induced by a CB1 receptor agonist.
Paper Details　
Original Abstract of the Article :
Cannabinoid-mediated memory impairment is a concern in cannabinoid-based therapies. Caffeine exacerbates cannabinoid CB<sub>1</sub> receptor (CB<sub>1</sub>R)-induced memory deficits through an adenosine A<sub>1</sub> receptor-mediated mechanism. We now evaluated how chronic or acute blockade of ade...See full text at original site
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引用元：
https://doi.org/10.1016/j.neuropharm.2017.02.021

データ提供：米国国立医学図書館（NLM）

Balancing Cannabinoids and Memory: A Tale of Two Receptors

This study, published in [Journal Name], explores the complex interplay between cannabinoid CB1 receptors (CB1Rs) and adenosine A2A receptors (A2ARs) in mediating memory formation. The researchers meticulously investigate the impact of blocking A2ARs on long-term episodic memory deficits induced by acute activation of CB1Rs, a phenomenon relevant to cannabinoid-based therapies.

The Role of A2ARs in Cannabinoid-Induced Memory Impairment

The study reveals that chronic or acute blockade of A2ARs effectively prevents the long-term memory disruption caused by acute CB1R activation. This finding suggests that A2ARs play a crucial role in mediating the cognitive side effects of cannabinoid exposure.

Navigating the Landscape of Cannabinoid Therapies

This research has important implications for the development and application of cannabinoid-based therapies. By understanding the interactions between CB1Rs and A2ARs, we can optimize treatment strategies to minimize cognitive side effects and maximize therapeutic benefits.

Dr. Camel's Conclusion

This study highlights the delicate balance between cannabinoids and memory. Just as a desert traveler navigates the shifting sands, researchers must carefully consider the intricate interplay of neurotransmitter systems to achieve optimal outcomes in therapeutic interventions.

Date :
  1. Date Completed 2018-05-03
  2. Date Revised 2021-02-23
Further Info :

Pubmed ID

28235548

DOI: Digital Object Identifier

10.1016/j.neuropharm.2017.02.021

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