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Effects of incorporation of 6-thioguanine into SV40 DNA.

Author: AjmeraS, BainnsonA N, IwaniecL M, KrollJ J, MaybaumJ, RoethelW M, TerBushD R

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

6-thioguanine (TG), an antileukemic agent, inhibits DNA synthesis by interfering with initiation of replication. The effect was correlated with TG incorporation into viral DNA.
Paper Details　
Original Abstract of the Article :
The antileukemic agent 6-thioguanine (TG) is thought to inhibit DNA synthesis as a result of its incorporation into DNA. In the present study we have examined the nature of this inhibition, using replication of SV40 viral DNA as a model system. Addition of TG to SV40-infected CV1P cells from 22 to 2...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2824979

データ提供：米国国立医学図書館（NLM）

Understanding the Impact of 6-Thioguanine on DNA Replication

This research delves into the molecular mechanisms of 6-thioguanine (TG), an antileukemic agent, and its effect on DNA replication. The researchers used a model system involving SV40 viral DNA replication to investigate how TG inhibits DNA synthesis. The study aimed to understand the specific mechanisms of TG's action and whether it affects the initiation or elongation of DNA replication.

The study found that TG inhibits DNA synthesis by interfering with the initiation of replication, potentially by substituting for guanine in key recognition sequences at the origin of replication.

A Deeper Understanding of Antileukemic Drugs

This research provides valuable insights into the molecular mechanisms of TG, a commonly used antileukemic drug. Understanding how TG interacts with DNA can help to refine its use and potentially develop more effective and targeted therapies for leukemia.

The Importance of Molecular Mechanisms

This research emphasizes the importance of understanding the molecular mechanisms of drugs, especially those that interact with DNA. Just as a desert traveler needs to understand the properties of different sands and terrains, researchers must delve into the molecular details of drugs to optimize their use and minimize potential side effects.

Dr. Camel's Conclusion

This research is like a journey through the intricate desert landscape of DNA replication, revealing the complex interactions between drugs and the molecules of life. By understanding these interactions, we can develop more effective and targeted treatments for various diseases.

Date :
  1. Date Completed 1988-01-06
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

2824979

DOI: Digital Object Identifier

2824979

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・Effects of thioguanine
SNS
PICO Info
in preparation
Languages

English

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