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Inhibitory Effects of Garcinia cambogia Extract on CYP2B6 Enzyme Activity.
Author: ChoiMin Sun, NakamuraKatsunori, ParkJong Suk, RehmanShaheed Ur, YooHye Hyun, YuJun Sang
Original Abstract of the Article :
This study assessed the inhibitory effects of <i>Garcinia cambogia</i> extract on the cytochrome P450 enzymes <i>in vitro. G. cambogia</i> extract was incubated with cytochrome P450 isozyme-specific substrates in human liver microsomes and recombinant CYP2B6 isozyme, and the formation of the marker ...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
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引用元：
https://doi.org/10.1055/s-0043-104934
データ提供：米国国立医学図書館（NLM）
A Tropical Fruit's Potential: *Garcinia cambogia* and CYP2B6 Enzyme Activity
The world of enzymes is a bustling marketplace, with countless players involved in the intricate process of breaking down and metabolizing substances in our bodies. CYP2B6, one of these enzymes, plays a crucial role in the metabolism of various medications. This research explores the potential impact of *Garcinia cambogia*, a tropical fruit known for its weight-loss properties, on the activity of CYP2B6.
The study investigates the effects of *Garcinia cambogia* extract on the activity of CYP2B6 in human liver microsomes and recombinant CYP2B6. The findings suggest that *Garcinia cambogia* extract can significantly inhibit the activity of CYP2B6, potentially affecting the metabolism of medications that rely on this enzyme. This inhibition is time-dependent, meaning the effects of *Garcinia cambogia* extract on CYP2B6 activity increase over time.
Navigating the Marketplace: Potential Interactions with *Garcinia cambogia*
The study findings highlight the potential for interactions between *Garcinia cambogia* extract and medications metabolized by CYP2B6. This is important to note for those who use *Garcinia cambogia* for weight loss or other purposes, as it could lead to unexpected effects on medication efficacy.
A Careful Balance: Understanding the Potential for Drug Interactions
This research underscores the importance of understanding the potential for interactions between natural supplements and medications. While *Garcinia cambogia* may offer potential health benefits, it's essential to be aware of its potential impact on CYP2B6 activity and the possible implications for medication efficacy.
Dr. Camel's Conclusion
This study sheds light on the potential for *Garcinia cambogia* extract to affect the activity of CYP2B6, a vital enzyme in the metabolism of medications. It underscores the need for caution when combining *Garcinia cambogia* with medications metabolized by CYP2B6, ensuring a balanced and safe journey through the marketplace of metabolic processes.
Date :
- Date Completed 2017-12-05
- Date Revised 2017-12-05
Further Info :
Related Literature
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