Low doses of tizanidine synergize the anti-nociceptive and anti-inflammatory effects of ketorolac or naproxen while reducing of side effects.

Author: Beltrán-VillalobosKarla, Castro-VidalDalia A, Déciga CamposMyrna, Flores-MurrietaFrancisco J, Montiel-RuizRosa M, Patiño-CamachoSelene I

Paper Details 
Original Abstract of the Article :
The aim of the present study was to determine whether tizanidine, an alpha2-adrenoceptor agonist, is able to increase the anti-inflammatory and anti-nociceptive effects of naproxen and ketorolac with a low incidence of gastric injury and spontaneous activity in rats. The anti-inflammatory effect was...See full text at original site
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引用元:
https://doi.org/10.1016/j.ejphar.2017.03.021

データ提供:米国国立医学図書館(NLM)

Low Doses of Tizanidine Synergize Anti-Nociceptive and Anti-Inflammatory Effects of Ketorolac and Naproxen

This research investigates the potential of tizanidine, an alpha2-adrenoceptor agonist, to enhance the anti-inflammatory and anti-nociceptive effects of naproxen and ketorolac, while minimizing side effects. The study found that tizanidine, when combined with naproxen or ketorolac, significantly improved their anti-inflammatory and anti-nociceptive efficacy. Moreover, tizanidine reduced the gastrointestinal side effects associated with these drugs. These findings suggest a potential therapeutic advantage for tizanidine in the management of inflammation and pain.

Tizanidine: A Potential Game Changer for Pain Management

This research suggests that tizanidine could provide a more effective and tolerable approach to managing pain and inflammation. The synergistic effects of tizanidine with naproxen and ketorolac, along with its ability to reduce gastrointestinal side effects, hold significant promise for pain relief. It's like finding a cool oasis in the desert of pain, offering relief and comfort without the harsh side effects.

Tizanidine: A New Frontier in Pain Management

This research opens new avenues for pain management. The combination of tizanidine with naproxen or ketorolac presents a promising strategy for achieving better pain control with fewer side effects. It's like discovering a new desert route that leads to a more comfortable and effective destination for pain relief.

Dr. Camel's Conclusion

This research demonstrates the potential for a multi-pronged approach to pain management. Like a wise camel navigating the desert, this research suggests that combining different strategies can lead to a more effective and comfortable journey through pain.

Date :
  1. Date Completed 2017-11-08
  2. Date Revised 2017-11-08
Further Info :

Pubmed ID

28315341

DOI: Digital Object Identifier

10.1016/j.ejphar.2017.03.021

SNS
PICO Info
in preparation
Languages

English

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