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Effects of Buprenorphine, Methylnaltrexone, and Their Combination on Gastrointestinal Transit in Healthy New Zealand White Rabbits.

Author: BrooksElizabeth P, Martin-FloresManuel, MitchellLisa M, SinghBhupinder, TaylorLacic, WalshCourtney A

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Methylnaltrexone did not alleviate buprenorphine-induced gastrointestinal stasis, reduced food and water consumption, and prolonged gastrointestinal transit time in rabbits.
Paper Details　
Original Abstract of the Article :
Among the many analgesic agents available, buprenorphine appears to be the analgesic used most often in rabbits. Unfortunately, deleterious side effects of opioids, such as gastrointestinal stasis and anorexia, may discourage the use of these agents. Methylnaltrexone is a peripheral opioid antagonis...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361040/

データ提供：米国国立医学図書館（NLM）

Buprenorphine and Methylnaltrexone: A Tale of Two Medications

Buprenorphine is a commonly used painkiller for rabbits, but it can have side effects such as digestive problems. This study investigates the use of methylnaltrexone, a medication that blocks the effects of opioids in the digestive system, to counteract the negative gastrointestinal side effects of buprenorphine in rabbits.

Buprenorphine and Methylnaltrexone: A Complex Interaction

The researchers found that while buprenorphine did indeed cause digestive issues, including slowed digestion and decreased food intake, methylnaltrexone did not effectively reverse these side effects. This suggests that methylnaltrexone may not be a suitable solution for addressing the digestive problems associated with buprenorphine in rabbits. Further research is needed to find effective ways to manage these side effects.

A Search for Solutions

This study highlights the need for further research into managing the gastrointestinal side effects of opioids in animals. Finding effective ways to address these problems is crucial for ensuring the well-being of animals that require pain management. It's important to consult with your veterinarian about any concerns regarding your pet's medication and side effects.

Dr.Camel's Conclusion

Imagine a camel trying to navigate a desert with a heavy load on its back. Sometimes, medications can cause similar burdens on our bodies. This research sheds light on the complex interplay between medications, reminding us that finding solutions for side effects is crucial for overall well-being.

Date :
  1. Date Completed 2017-08-16
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

28315644

DOI: Digital Object Identifier

PMC5361040

Related Literature

Article Analysis
・Side Effects of methylnaltrexone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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