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Influence of Proton Pump Inhibitors on Mycophenolic Acid Pharmacokinetics in Patients With Renal Transplantation and the Relationship With Cytochrome 2C19 Gene Polymorphism.
Author: AydinF, CaliskanY, CiftciH S, DemirE, KaradenizM S, NaneI, OguzF S, TefikT, TurkmenA, YazıcıH
Original Abstract of the Article :
Most patients have serious digestive complications after renal transplantation. Therefore, it is important to protect gastrointestinal function to improve the survival rate of transplant patients. Proton pump inhibitors (PPIs) such as lansoprazole and rabeprazole are widely administered to renal tra...See full text at original site
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引用元：
https://doi.org/10.1016/j.transproceed.2017.01.029
データ提供：米国国立医学図書館（NLM）
Proton Pump Inhibitors and Mycophenolic Acid: Navigating the Desert of Drug Interactions
Renal transplantation, a life-saving procedure, can be accompanied by digestive complications. Proton pump inhibitors (PPIs), such as lansoprazole and rabeprazole, are often used to protect the gastrointestinal system in these patients. However, PPIs interact with mycophenolic acid (MPA), a crucial immunosuppressant drug, which can impact its effectiveness. This study investigates the interplay between PPIs and MPA, focusing on the role of CYP2C19 polymorphisms, genetic variations that influence drug metabolism. By delving into the complex landscape of drug interactions, the study aims to optimize immunosuppressive therapy after renal transplantation.
A delicate balance in the desert of drug interactions
The study uncovered the complex relationship between PPIs and MPA. CYP2C19 polymorphisms significantly influenced the pharmacokinetics of MPA, highlighting the importance of personalized medicine in transplant patients. This research offers crucial information for healthcare providers in optimizing immunosuppressive regimens, ensuring optimal patient outcomes.
Navigating the desert with caution: Implications for transplant patients
This study underscores the importance of understanding drug interactions in transplant patients. It's crucial to consider individual genetic factors and potential drug interactions to ensure optimal immunosuppression while minimizing adverse effects. This is a complex area requiring careful monitoring and tailored management by healthcare professionals.
Dr. Camel's Conclusion
The desert of drug interactions can be treacherous, but this study offers a roadmap for safe and effective immunosuppression in renal transplant patients. By navigating the complex terrain of genetic variations and drug interactions, we can help patients thrive in the post-transplant landscape.
Date :
- Date Completed 2017-05-16
- Date Revised 2018-12-02
Further Info :
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