Paper Details

  1. Home
  2. Paper Details

Topical Delivery of Fenoprofen Calcium via Elastic Nano-vesicular Spanlastics: Optimization Using Experimental Design and In Vivo Evaluation.

Author: AboelwafaAhmed A, FarghalyDalia Ali, HamzaManal Y, MohamedMagdy I

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the topical delivery of fenoprofen calcium (FPCa) using a surfactant-based nanovesicular system (spanlastics) to avoid oral gastrointestinal adverse effects. The optimized spanlastic gel formulation showed high drug entrapment efficiency (49.91 ± 2.60%), prolonged release, and three times higher inhibition of rat paw edema compared to conventional FPCa gel, suggesting it is a promising approach for treating arthritis.
Paper Details　
Original Abstract of the Article :
The aim of this study was to investigate the potential of surfactant-based nanovesicular system (spanlastics) for topical delivery of fenoprofen calcium (FPCa) to eliminate its oral gastrointestinal adverse effects. FPCa-loaded spanlastics were prepared by thin film hydration (TFH) technique accordi...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1208/s12249-017-0771-8

データ提供：米国国立医学図書館（NLM）

Fenoprofen Calcium: A Journey Through Nano-Vesicles

Fenoprofen calcium, a drug used to treat pain and inflammation, can sometimes cause unwanted side effects in the digestive system. This research explores the potential of a nano-vesicular system, like tiny treasure chests filled with fenoprofen calcium, to deliver the drug topically and minimize these side effects, creating a smoother journey for patients.

Delivering Relief with Precision

The researchers carefully designed a nano-vesicular system, like skilled artisans crafting a delicate mosaic. They found that this system improved the delivery of fenoprofen calcium to the skin, potentially reducing the need for oral administration and minimizing gastrointestinal side effects.

Easing the Burden of Pain and Inflammation

This research opens a new chapter in drug delivery, suggesting that nano-vesicles could offer a more targeted and efficient way to deliver medications. It could lead to new treatment options for various conditions, including arthritis, where topical pain relief is essential.

Dr.Camel's Conclusion

This study, like a desert caravan laden with precious goods, provides a novel approach to drug delivery. It highlights the potential of nano-vesicles to revolutionize treatment options, creating a more comfortable and effective experience for patients seeking relief from pain and inflammation.

Date :
  1. Date Completed 2018-05-09
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

28429293

DOI: Digital Object Identifier

10.1208/s12249-017-0771-8

Related Literature

Article Analysis
・Effects of fenoprofen
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.