Prescriber Compliance With Liver Monitoring Guidelines for Pazopanib in the Postapproval Setting: Results From a Distributed Research Network.

Author: ChaginKaren, DjousseLuc, FraemanKathy H, GagnonDavid R, HallSusan A, NelsonJeanenne J, NordstromBeth L, ShantakumarSumitra, van Herk-SukelMyrthe P P

Paper Details 
Original Abstract of the Article :
Pazopanib received US Food and Drug Administration approval in 2009 for advanced renal cell carcinoma. During clinical development, liver chemistry abnormalities and adverse hepatic events were observed, leading to a boxed warning for hepatotoxicity and detailed label prescriber guidelines for liver...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407814/

データ提供:米国国立医学図書館(NLM)

Pazopanib: Assessing Prescriber Compliance with Liver Monitoring Guidelines

This study focuses on the important issue of [drug safety] and investigates prescriber compliance with liver monitoring guidelines for pazopanib, a medication used to treat advanced renal cell carcinoma. The study aimed to assess the extent to which prescriber practices aligned with the detailed guidelines outlined in the drug's label, which include a boxed warning for hepatotoxicity. The researchers conducted a [cohort study] using data from a distributed research network to analyze prescriber practices in the post-approval setting. The study concluded that prescriber compliance with liver monitoring guidelines for pazopanib varied significantly, highlighting the need for enhanced education and awareness among prescribers regarding the importance of vigilant liver monitoring in patients receiving this medication. The study emphasizes the crucial role of healthcare professionals in ensuring patient safety by adhering to established guidelines.

Pazopanib: Assessing Prescriber Compliance with Liver Monitoring Guidelines

This study highlights the importance of prescriber compliance with liver monitoring guidelines for pazopanib. The study found that compliance varied significantly, underscoring the need for enhanced education and awareness among prescribers regarding the importance of vigilant liver monitoring in patients receiving this medication.

Pazopanib: Assessing Prescriber Compliance with Liver Monitoring Guidelines

Imagine pazopanib as a powerful desert plant, capable of battling cancer but also carrying the risk of liver toxicity. Liver monitoring guidelines act like a skilled desert guide, providing essential instructions for safely navigating the terrain. This study suggests that we need to improve the awareness of these guidelines among desert explorers (prescribers) to ensure the safe use of this powerful medicine.

Dr.Camel's Conclusion

This study emphasizes the importance of prescriber compliance with liver monitoring guidelines for pazopanib. The study found that compliance varied significantly, underscoring the need for enhanced education and awareness among prescribers regarding the importance of vigilant liver monitoring in patients receiving this medication.

Date :
  1. Date Completed 2020-04-28
  2. Date Revised 2021-12-04
Further Info :

Pubmed ID

28430700

DOI: Digital Object Identifier

PMC6407814

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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