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Efficacy and safety of rectal 5-aminosalicylic acid versus corticosteroids in active distal ulcerative colitis: a systematic review and network meta-analysis.

Author: MaHaiqin, MaJingjing, SunMin, WangPeixue, ZhangHongjie, ZhangYi, ZhaoXiaojing, ZhouChangcheng, ZhuYunjuan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This study compared the efficacy and safety of different topical medications for active distal ulcerative colitis (UC), including 5-aminosalicylic acid (5-ASA) and corticosteroids. The combination of topical 5-ASA and Beclomethasone dipropionate (BDP) showed the highest probability of achieving clinical and endoscopic remission, suggesting it is a potential treatment option for active distal UC.
Paper Details　
Original Abstract of the Article :
Topical 5-aminosalicylic acid (5-ASA) and corticosteroids are used frequently in the treatment of active distal ulcerative colitis (UC). Our study aimed to determine the efficacy and safety of different topical drugs used to treat active distal UC. A random-effects model within a Bayesian framework ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404224/

データ提供：米国国立医学図書館（NLM）

Treating Active Distal Ulcerative Colitis: A Comparative Analysis of Topical Medications

Gastroenterology continues to explore effective treatment options for inflammatory bowel diseases, including ulcerative colitis. This research compares the efficacy and safety of different topical medications for the treatment of active distal ulcerative colitis (UC).

Combined Therapy of 5-ASA and BDP: A Promising Approach

The systematic review and network meta-analysis found that combined therapy with topical 5-aminosalicylic acid (5-ASA) and beclomethasone dipropionate (BDP) showed the highest probability of being the best regimen for achieving clinical and endoscopic remission in active distal UC. This finding suggests that combined therapy may offer significant advantages over other treatment options.

Implications for Ulcerative Colitis Management and Treatment Strategies

This research provides valuable information for doctors seeking to manage active distal UC. It suggests that combining topical 5-ASA and BDP may be an effective and well-tolerated approach. This discovery is like finding a new oasis in the desert of UC treatment, offering a promising path towards remission and improved quality of life for patients.

Dr.Camel's Conclusion

This research highlights the potential benefits of combined therapy with topical 5-ASA and BDP for treating active distal UC. Like finding a hidden oasis in a desert of discomfort, this research offers a promising approach to managing this challenging condition.

Date :
  1. Date Completed 2019-08-21
  2. Date Revised 2019-08-21
Further Info :

Pubmed ID

28440311

DOI: Digital Object Identifier

PMC5404224

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English

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