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[ACTION OF L-CARNITINE, CORVITIN AND THEIR COMBINATION ON FUNCTIONAL STATE OF LIVER IN EXPERIMENTAL MODEL OF REYE SYNDROME IN RATS].

Author: AntelavaN, GhonghadzeM, LiluashviliK, OkujavaM, PachkoriaK

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study evaluated the efficacy of L-carnitine, Corvitin, and their combination in treating an experimental model of Reye syndrome in rats. Monotherapy with L-carnitine or Corvitin improved liver function. However, combined treatment showed the most significant hepatoprotective effects, suggesting that combining these drugs may be a promising therapeutic approach for treating Reye syndrome.
Paper Details　
Original Abstract of the Article :
Administration of Aacetylsalicylic acid in children with viral infections (influence B, chickenpox) can be related with development of Reye syndrome - severe encephalopathy and liver insufficiency with mortality in 50% of cases. During Reye syndrome most important is deficiency of carnitine and hepa...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/28452736

データ提供：米国国立医学図書館（NLM）

Combating Reye Syndrome: A Synergistic Approach

Reye syndrome, a rare but serious condition primarily affecting children, can lead to severe liver dysfunction and encephalopathy. This research investigates the potential of L-Carnitine, Corvitin, and their combination in treating an experimental model of Reye syndrome in rats. The study aims to determine the efficacy of these treatments in improving liver function and reducing the severity of the syndrome.

Synergistic Effects for Liver Protection

The study demonstrated that both L-Carnitine and Corvitin, individually, effectively improved liver function and reduced markers of hepatocyte damage. However, the combination of these two drugs showed a synergistic effect, resulting in a more pronounced hepatoprotective effect and no mortality in the treated rats. This finding suggests that a combined approach with both L-Carnitine and Corvitin may be more effective in managing Reye syndrome.

A Promising Avenue for Treatment

This research provides encouraging evidence for the potential of L-Carnitine and Corvitin, particularly in combination, in managing Reye syndrome. Further research is needed to investigate the effectiveness of this treatment in humans. However, this study offers hope for developing new strategies to combat this serious condition.

Dr.Camel's Conclusion

Just as a camel needs to navigate a desert landscape with resilience, treating Reye syndrome requires a multi-faceted approach. This research highlights the potential of a synergistic combination of L-Carnitine and Corvitin in improving liver function and reducing the severity of Reye syndrome. It's a reminder that collaborative efforts can lead to promising solutions for challenging health conditions.

Date :
  1. Date Completed 2017-07-31
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

28452736

DOI: Digital Object Identifier

28452736

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・Effective treatment of reye syndrome
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in preparation
Languages

Russian

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