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Thioridazine has potent antitumor effects on lung cancer stem-like cells.

Author: ChuLiang, HanJiancui, MaBuyun, ShenJiani, SunXiaozhu, WangYigang, XuHaineng, YangYu, ZhangXinmin

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the effect of thioridazine (TDZ) on lung cancer stem-like cells. The authors found that TDZ elicited cytotoxicity in A549 sphere cells, inhibited their proliferation, and repressed growth of lung cancer stem-like cells in vivo. These findings suggest that TDZ may have potential as a therapeutic agent for targeting lung cancer stem-like cells.
Paper Details　
Original Abstract of the Article :
Thioridazine (TDZ), originally an anti-psychotic drug, suppresses several types of cancer and has specificity for leukemia stem cells. The present study was performed to assess its effect on lung cancer stem-like cells, as its effect remains unknown. TDZ was utilized to treat lung cancer stem-like c...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403693/

データ提供：米国国立医学図書館（NLM）

Thioridazine's Impact on Lung Cancer Stem-Like Cells

Lung cancer, a complex and often aggressive disease, can feel like a vast and unforgiving desert. This study investigates the potential of thioridazine, a drug originally developed as an antipsychotic, to target lung cancer stem-like cells. The researchers found that thioridazine exhibited significant antitumor effects against these cells, both in laboratory settings and in animal models.

Novel Therapeutic Strategies for Lung Cancer

This study suggests that thioridazine could be a promising new therapeutic agent for treating lung cancer, particularly targeting the cancer stem cells that contribute to tumor growth and recurrence.

Fighting Lung Cancer Stem Cells

The findings could lead to the development of new treatment strategies for lung cancer, potentially improving outcomes for patients struggling with this challenging disease.

Dr. Camel's Conclusion

This research offers hope for patients with lung cancer, suggesting that thioridazine could be a valuable tool in the fight against this devastating disease.

Date :
  1. Date Completed n.d.
  2. Date Revised 2020-10-01
Further Info :

Pubmed ID

28454291

DOI: Digital Object Identifier

PMC5403693

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PICO Info
in preparation
Languages

English

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