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Results of the therapy of acute leukemia. A cooperative trial by the Italian Association Against Leukemias.

Author: PolliE E

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A study of 157 patients with acute lymphoblastic leukemia found that 92.3% achieved complete remission. Patients under 20 years old had a 3-year remission rate of 60%. Age, lymph node involvement, and the percentage of periodic acid-Schiff-positive blast cells were identified as potential prognostic factors. Two maintenance chemotherapy regimens (A and B) were compared, with regimen A showing better results in children aged 2-10 years and patients with mild lymph node enlargement. Based on these findings, three new protocols incorporating prognostic factors were developed, resulting in 1-year remission rates of 91% for Protocol 7601, 70% for Protocol 7602, and 82% for Protocol 7603.
Paper Details　
Original Abstract of the Article :
Protocol 7401 for the treatment of acute lymphoblastic leukemia was carried out by the study group of the Italian Association Against Leukemias. The 157 patients studied were divided into two groups--over and under 20 years of age. Patients reaching complete remission were then randomized into one o...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/285045

データ提供：米国国立医学図書館（NLM）

Navigating the Shifting Sands: Treatment of Acute Leukemia

The treatment of acute leukemia, a complex and challenging disease, requires a multifaceted approach. This study, conducted by the Italian Association Against Leukemias, explored the effectiveness of different chemotherapy regimens for patients with acute lymphoblastic leukemia. The researchers divided 157 patients into two groups based on age, evaluating the effectiveness of various treatment protocols and analyzing the prognostic factors influencing patient outcomes.

A Collaborative Effort to Combat Leukemia

This study exemplifies the importance of collaborative research in addressing complex diseases like acute leukemia. The researchers worked together, pooling their expertise and resources to investigate the effectiveness of different treatment approaches. The study's findings provide valuable insights into the factors that contribute to patient outcomes, aiding in the development of more effective treatment strategies.

Improving Patient Survival and Quality of Life

The research highlights the importance of tailoring treatment plans based on individual patient characteristics, including age, disease presentation, and prognostic factors. This personalized approach can contribute to better patient outcomes, potentially leading to higher remission rates and improved survival. The study underscores the need for ongoing research and innovation to improve the treatment of acute leukemia and enhance patients' quality of life.

Dr.Camel's Conclusion

Like a camel navigating the shifting sands of a desert, the treatment of acute leukemia requires a thoughtful and adaptive approach. This research provides valuable insights into the effectiveness of different treatment strategies, showcasing the power of collaboration and personalized care in addressing this challenging disease. It’s a reminder that with every step forward in research, we inch closer to conquering this formidable foe.

Date :
  1. Date Completed 1979-06-11
  2. Date Revised 2017-11-17
Further Info :

Pubmed ID

285045

DOI: Digital Object Identifier

285045

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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