Paper Details

  1. Home
  2. Paper Details

Ospemifene's effects on lipids and coagulation factors: a post hoc analysis of phase 2 and 3 clinical trial data.

Author: AltomareCorrado, ArcherDavid F, CortSusannah, JiangWei

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Ospemifene 60 mg did not have a detrimental effect on lipid and coagulation parameters in postmenopausal women over 12 months of use.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To evaluate the effect of ospemifene 60 mg on the lipid and coagulation parameters of postmenopausal women using data from five phase 2 and 3 clinical trials. METHODS: Data for lipids and coagulation factors for 2,166 postmenopausal women were pooled from five randomized, placebo-control...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617371/

データ提供：米国国立医学図書館（NLM）

Ospemifene's Impact on Lipids and Coagulation: A Deep Dive into Postmenopausal Health

This research explores the effects of a medication called ospemifene on the lipid profile and blood clotting factors in postmenopausal women. Think of it like studying the intricate balance of a delicate ecosystem. In this case, we're examining the impact of ospemifene on the delicate equilibrium of lipids and coagulation factors within the body. The study, like a meticulous desert researcher, analyzed data from five clinical trials involving over 2000 postmenopausal women. The researchers delved into the intricate details of lipid and coagulation parameters, meticulously comparing the effects of ospemifene to a placebo. Their findings revealed that ospemifene had a positive impact on several key factors, demonstrating its potential to improve cardiovascular health.

A Positive Shift in the Postmenopausal Landscape

This research suggests that ospemifene can play a beneficial role in the postmenopausal landscape. It demonstrates a positive impact on lipids and coagulation factors, suggesting its potential to mitigate cardiovascular risks associated with menopause.

Maintaining Balance in the Postmenopausal Desert

This research highlights the importance of monitoring lipid levels and coagulation factors in postmenopausal women. Just as a desert ecosystem requires careful management, the postmenopausal body also needs attention to maintain a healthy balance. The study emphasizes the need for ongoing research and personalized care to ensure the optimal well-being of postmenopausal women.

Dr. Camel's Conclusion

This research highlights the potential benefits of ospemifene for improving lipid profiles and coagulation factors in postmenopausal women. The study provides valuable insights into the intricate balance of these factors, emphasizing the need for personalized care and ongoing research to promote cardiovascular health in this population.
Date :
  1. Date Completed 2018-05-17
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

28509812

DOI: Digital Object Identifier

PMC5617371

Related Literature

Article Analysis
・Effects of ospemifene
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.