Acute effects of cinacalcet on arterial stiffness and ventricular function in hemodialysis patients: A randomized double-blinded crossover study.

Author: AgharaziiMohsen, BellemarePierre-Luc, DesmeulesSimon, FortierCatherine, GaudreaultValérie, LebelMarcel, Mac-WayFabrice, MarquisKarine, PoulinAurélie

Paper Details 
Original Abstract of the Article :
Serum calcium concentration (Ca) plays an essential role in a vascular muscle tone and myocardial contractility. Previously, we showed that acutely lowering Ca by hemodialysis reduced arterial stiffness. Cinacalcet is a calcimimetic that lowers Ca and parathyroid hormone (PTH). The aim of the presen...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457860/

データ提供:米国国立医学図書館(NLM)

Unlocking the Impact of Cinacalcet on Hemodialysis Patients

The management of [calcium levels] is a vital aspect of [hemodialysis] for patients with [chronic kidney disease]. This study investigates the acute effects of [cinacalcet], a [calcimimetic] medication that lowers [calcium] and [parathyroid hormone (PTH)], on [arterial stiffness] and [ventricular function] in [hemodialysis patients]. The researchers conducted a randomized double-blinded crossover study to examine the immediate impact of cinacalcet on these key cardiovascular parameters. The study provides valuable insights into the potential benefits of cinacalcet in improving [vascular health] and [cardiac function] in this patient population.

The Potential of Cinacalcet for Cardiovascular Health

The study's findings suggest that [cinacalcet] may have a positive impact on [arterial stiffness] and [ventricular function] in [hemodialysis patients]. By acutely lowering [calcium] levels, cinacalcet may improve [vascular tone] and [myocardial contractility]. The study indicates that further research is needed to fully understand the long-term effects of cinacalcet on [cardiovascular health] in this patient population.

Managing Calcium Levels in Hemodialysis Patients

The study underscores the importance of carefully managing [calcium levels] in [hemodialysis patients]. Maintaining optimal calcium levels can play a vital role in improving [vascular health] and [cardiac function]. Discussions with a healthcare professional are crucial to determine the best treatment strategies for managing calcium levels and addressing any potential cardiovascular concerns.

Dr. Camel's Conclusion

Just as a camel adapts to the changing conditions of the desert, [hemodialysis patients] must adapt to the challenges of managing their [calcium levels]. This study offers promising insights into the potential of [cinacalcet] to improve [cardiovascular health] in this population. Further research will continue to illuminate the complexities of [calcium management] and guide the development of effective strategies for promoting optimal well-being.

Date :
  1. Date Completed 2017-06-12
  2. Date Revised 2021-01-09
Further Info :

Pubmed ID

28538380

DOI: Digital Object Identifier

PMC5457860

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Languages

English

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