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Amorphous Solid Dispersion of Meloxicam Enhanced Oral Absorption in Rats With Impaired Gastric Motility.

Author: MatsunagaSaori, OnoueSatomi, SatoHideyuki, SetoYoshiki, SuzukiHiroki, YakushijiKeisuke, YamauchiYukinori

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study aimed to develop amorphous solid dispersions (ASDs) of meloxicam (MEL) to enhance its oral absorption in patients with severe pain, specifically addressing the issue of delayed gastric motility. The results suggest that ASD formulations of MEL with hydroxypropylmethylcellulose can significantly improve oral absorption compared to crystalline MEL.
Paper Details　
Original Abstract of the Article :
Meloxicam (MEL) shows a slow onset of action in severe pain patients on account of delayed gastric motility. This study aimed to develop an amorphous solid dispersion (ASD) of MEL to achieve rapid oral absorption in severe pain patients. ASD formulations of MEL with hydroxypropylmethylcellulose (ASD...See full text at original site
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引用元：
https://doi.org/10.1016/j.xphs.2017.05.023

データ提供：米国国立医学図書館（NLM）

Amorphous Solid Dispersion of Meloxicam: Enhancing Oral Absorption in Patients with Impaired Gastric Motility

The journey of drug delivery can be complex and challenging, like navigating a winding desert path. This study explores the potential of amorphous solid dispersion (ASD) to enhance the oral absorption of meloxicam, a nonsteroidal anti-inflammatory drug, in patients with impaired gastric motility.

Amorphous Solid Dispersion: A Novel Approach for Enhancing Meloxicam Absorption

The study demonstrates that ASD formulations of meloxicam significantly improve oral absorption in rats with impaired gastric motility, showcasing the potential of this approach to enhance drug delivery in patients with gastrointestinal issues. Think of ASD as a skilled camel driver, navigating the challenging desert terrain of impaired gastric motility to deliver the drug efficiently to its destination.

Improving Drug Delivery in Patients with Gastrointestinal Issues

This study highlights the potential of ASD formulations to enhance drug delivery in patients with impaired gastric motility. Like finding a hidden oasis in the desert, this novel approach offers a solution for patients experiencing difficulties in absorbing medications.

Dr.Camel's Conclusion

Amorphous solid dispersion offers a promising approach for enhancing the oral absorption of meloxicam in patients with impaired gastric motility. Just as a skilled camel driver utilizes the desert terrain to their advantage, this novel approach seeks to overcome challenges in drug delivery and optimize therapeutic outcomes.
Date :
  1. Date Completed 2018-07-24
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

28551427

DOI: Digital Object Identifier

10.1016/j.xphs.2017.05.023

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Languages

English

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