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Front-line glioblastoma chemotherapeutic temozolomide is toxic to Trypanosoma brucei and potently enhances melarsoprol and eflornithine.

Author: RushworthStuart A, SteverdingDietmar

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the in vitro activity of temozolomide, an anti-glioblastoma drug, against Trypanosoma brucei, the parasite causing sleeping sickness. The findings suggest that temozolomide may be a promising new drug for treating the second stage of sleeping sickness, particularly when used in combination with existing trypanocides.
Paper Details　
Original Abstract of the Article :
Sleeping sickness is an infectious disease that is caused by the protozoan parasite Trypanosoma brucei. The second stage of the disease is characterised by the parasites entering the brain. It is therefore important that sleeping sickness therapies are able to cross the blood-brain barrier. At prese...See full text at original site
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引用元：
https://doi.org/10.1016/j.exppara.2017.05.006

データ提供：米国国立医学図書館（NLM）

Temozolomide's Potential for Treating Sleeping Sickness

This study delves into the intriguing world of [parasitology], exploring the potential of [temozolomide], a drug typically used for [glioblastoma], to treat [sleeping sickness]. It's like discovering a hidden oasis in the vast desert of [infectious diseases]. The researchers discovered that [temozolomide] exhibits significant activity against [Trypanosoma brucei], the parasite responsible for [sleeping sickness], making it a promising candidate for treating this debilitating disease.

Temozolomide Shows Promise for Treating Sleeping Sickness

This study offers promising insights into the potential use of [temozolomide] for treating [sleeping sickness]. The researchers found that [temozolomide] effectively inhibits the growth of [Trypanosoma brucei] both alone and in combination with other trypanocides. This discovery could lead to new and more effective treatment options for patients suffering from [sleeping sickness].

Navigating the Desert of Sleeping Sickness Treatment

This study helps us navigate the desert of [sleeping sickness] treatment by highlighting the potential of [temozolomide] as a new and effective therapy. It's important to remember that every case of [sleeping sickness] is unique, like a unique sand dune in a vast desert. This study provides valuable insights into the potential of [temozolomide] and its ability to potentially improve treatment outcomes for patients with [sleeping sickness].

Dr.Camel's Conclusion

This study presents a fascinating discovery in the fight against [sleeping sickness]. The researchers demonstrate the potential of repurposing [temozolomide], a drug already used for [glioblastoma], to treat [sleeping sickness]. Their findings offer hope for developing new and more effective treatment options for this debilitating disease, potentially leading to improved outcomes for patients suffering from [sleeping sickness] and helping us navigate the desert of [infectious diseases] with greater success.
Date :
  1. Date Completed 2017-06-22
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

28552794

DOI: Digital Object Identifier

10.1016/j.exppara.2017.05.006

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・Side Effects of eflornithine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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