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Tolerability profile of thiopurines in inflammatory bowel disease: a prospective experience.

Author: AffrontiMarco, CottoneMario, DimarcoMariangela, MacalusoFabio Salvatore, MaidaMarcello, OrlandoAmbrogio, OrlandoEmanuele, OrlandoRosalba, RennaSara, RizzutoGiulia, SapienzaChiara, VentimigliaMarco

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This prospective cohort study showed that thiopurines, used to treat inflammatory bowel disease (IBD), had a high cumulative incidence of withdrawal due to adverse events. Switching from azathioprine (AZA) to 6-mercaptopurine (6-MP) was often ineffective.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: The occurrence of thiopurine-related adverse events (AEs) may complicate the management of patients with inflammatory bowel disease (IBD). We aimed to evaluate the tolerability of thiopurines in a current IBD setting. MATERIALS AND METHODS: All consecutive patients who started a treatme...See full text at original site
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引用元：
https://doi.org/10.1080/00365521.2017.1333626

データ提供：米国国立医学図書館（NLM）

Tolerability of Thiopurines in Inflammatory Bowel Disease: A Real-World Assessment

This research investigates the tolerability of thiopurines, a class of medications commonly used to treat inflammatory bowel disease (IBD). The authors conducted a prospective study to assess the incidence of thiopurine-related adverse events (AEs) in a real-world clinical setting.

Thiopurines: A Double-Edged Sword

The study found that a significant proportion of patients discontinued thiopurine treatment due to AEs. The most common AEs leading to drug withdrawal were nausea and poorly defined side effects, such as fatigue, headache, and muscle pain. These findings highlight the potential for thiopurines to cause significant side effects, even though they are often effective in managing IBD.

Navigating Thiopurine Therapy

The study emphasizes the importance of carefully monitoring patients on thiopurine therapy. The researchers recommend close observation for potential side effects and a proactive approach to managing these complications. They also suggest that switching from azathioprine to 6-mercaptopurine may not always be effective in mitigating side effects.

Dr.Camel's Conclusion

This study underscores the complex nature of thiopurine therapy for IBD. It highlights the need for careful patient selection, close monitoring, and a personalized approach to managing potential side effects. Like a camel traversing the unforgiving desert landscape, we must proceed with caution and vigilance when using thiopurines in the treatment of IBD.
Date :
  1. Date Completed 2018-04-30
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

28554266

DOI: Digital Object Identifier

10.1080/00365521.2017.1333626

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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