Ultraviolet A photosensitivity profile of dexchlorpheniramine maleate and promethazine-based creams: Anti-inflammatory, antihistaminic, and skin barrier protection properties.

Author: Alves PinheiroAna Lucia Tabarini, ClericiStefano Piatto, CostaAdilson, EberlinSamara, FacchiniGustavo

Paper Details 
Original Abstract of the Article :
BACKGROUND: Unwanted side effects such as dryness, hypersensitivity, and cutaneous photosensitivity are challenge for adherence and therapeutical success for patients using treatments for inflammatory and allergic skin response. AIMS: In this study, we compared the effects of two dermatological for...See full text at original site
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引用元:
https://doi.org/10.1111/jocd.12349

データ提供:米国国立医学図書館(NLM)

Unveiling the Secrets of UVA Photosensitivity: A Comparative Study of Creams

The [treatment of inflammatory and allergic skin conditions] often involves [topical creams], but these treatments can sometimes come with [unwanted side effects] such as [photosensitivity]. This study delves into the [phototoxicity potential] of [two commonly used creams] and compares their [anti-inflammatory] and [antihistaminic] properties. It's like venturing through a desert landscape, analyzing different plants for their unique properties.

UVA Photosensitivity: A Sun-Sensitive Desert Adventure

The study found that both creams, [dexchlorpheniramine maleate] and [promethazine], demonstrated [increased interleukin-1 synthesis] in response to UVA radiation. However, the researchers discovered that [dexchlorpheniramine maleate] exhibited a [lower irritant potential] and a [protective effect] on UVA-induced inflammation. It's like comparing two desert plants: one might cause a mild rash, while the other offers a soothing balm. These findings provide valuable insights into the [photosensitizing potential] of these creams and offer guidance for safer and more effective treatment options.

Skin Care in the Desert: Navigating the Sun's Rays

This study highlights the importance of [understanding the potential side effects] of [topical medications], especially in the context of [sun exposure]. It’s like navigating a desert, where the sun's rays can be both beneficial and dangerous. The research suggests that [dexchlorpheniramine maleate] may be a better choice for individuals seeking a [less irritant] and [more protective] cream. Remember to always consult with your dermatologist for personalized advice on skin care and sun protection.

Dr.Camel's Conclusion

This research emphasizes the importance of considering the photosensitizing potential of topical medications, particularly when exposed to UVA radiation. It's like understanding the delicate balance between the sun's warmth and its potential to burn. The study’s findings suggest that dexchlorpheniramine maleate offers a potentially safer and more effective option for managing inflammatory and allergic skin conditions compared to promethazine.

Date :
  1. Date Completed 2018-08-01
  2. Date Revised 2018-08-01
Further Info :

Pubmed ID

28593645

DOI: Digital Object Identifier

10.1111/jocd.12349

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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