Optimizing Thiopurine Therapy in Inflammatory Bowel Disease Among 2 Real-life Intercept Cohorts: Effect of Allopurinol Comedication?

Author: BoumaGerd, MeijerBerrie, MulderChris J J, SeinenMargien L, de BoerNanne K H, van BodegravenAdriaan A, van EgmondRemco

Paper Details 
Original Abstract of the Article :
Thiopurines (azathioprine and mercaptopurine) are frequently used immunosuppressive drugs to maintain remission in patients with inflammatory bowel disease. Half of the conventional thiopurine-derivative users have to discontinue treatment within 5 years, mainly because of intolerable adverse events...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647119/

データ提供:米国国立医学図書館(NLM)

Optimizing Thiopurine Therapy in Inflammatory Bowel Disease

This research focuses on the optimization of [thiopurine] therapy in patients with [inflammatory bowel disease] (IBD), a chronic inflammatory condition that affects the digestive system. The study explores the impact of [allopurinol] cotherapy on the tolerability and efficacy of [thiopurines] in managing IBD. This research aims to improve the effectiveness and safety of [thiopurine] therapy, minimizing the adverse events associated with these medications and improving patient outcomes.

Allopurinol: A Potential Tool for Optimizing Thiopurine Therapy

This research suggests that [allopurinol] cotherapy may improve the tolerability and efficacy of [thiopurine] therapy in patients with IBD. The study provides valuable insights into the potential benefits of this cotherapy strategy in optimizing treatment for IBD. The findings also highlight the importance of individualized approaches to treatment, taking into account the unique needs and circumstances of each patient. This research could lead to the development of more effective and well-tolerated treatment regimens for IBD.

Navigating the Challenges of Inflammatory Bowel Disease

This research emphasizes the ongoing need for effective management strategies for IBD, a condition that can significantly impact a patient's quality of life. The study highlights the importance of finding ways to optimize treatment regimens, minimizing side effects, and improving patient outcomes. This research offers a glimmer of hope in the desert of IBD, suggesting a potential path towards better treatment options and improved patient well-being.

Dr.Camel's Conclusion

This research underscores the importance of finding creative solutions to manage the challenges of IBD. The potential of [allopurinol] cotherapy to improve the tolerability and efficacy of [thiopurine] therapy is a promising development, potentially offering a path towards better treatment options and improved patient outcomes. Just as a camel navigates the desert with resilience and adaptability, we must continue to explore innovative strategies to manage this complex condition and improve the lives of those affected by IBD.
Date :
  1. Date Completed 2018-06-14
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

28617756

DOI: Digital Object Identifier

PMC5647119

Related Literature

SNS
PICO Info
in preparation
Languages

English

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