Retention of perampanel in adults with pharmacoresistant epilepsy at a single tertiary care center.

Author: DuncanJohn S, MannanShahidul, SanderJosemir W, ShankarRohit, TuragaSanchit, VallabhaneniKirtana, WehnerTim, WiggansCarys, YipHao Meng

Overview

This study describes the clinical experience with perampanel (PER) in a large UK tertiary epilepsy center. PER resulted in some benefit in 40% of those exposed, but adverse effects on mental health and balance were common.

Paper Details　

Original Abstract of the Article :

RATIONALE: Observational data on antiepileptic drugs (AEDs) inform about their use in clinical practice. We describe our clinical experience with perampanel (PER) in a large UK tertiary epilepsy center. METHODS: Adults initiated on PER between October 2012 and March 2015 were followed until they di...See full text at original site

Dr.Camel's Paper Summary Blog

Perampanel: Navigating the Landscape of Epilepsy Treatment

The world of epilepsy treatment is as intricate and complex as a sand dune landscape. This research sheds light on the use of perampanel (PER), a medication that aims to tame the unruly storms of seizures. The study, conducted at a prominent epilepsy center in the UK, explores the long-term effectiveness and side effects of PER in patients with pharmacoresistant epilepsy. This is like charting a new path in the desert, seeking the most effective treatment for a challenging condition.

The researchers meticulously followed patients who started PER, recording their seizure frequency, side effects, and medication adherence. The results reveal that PER was associated with some benefit in a significant number of patients, offering hope for improved seizure control. However, the study also highlights the importance of monitoring for side effects, particularly those related to mental health and balance.

While PER showed promise in managing seizures, the study emphasizes the need for careful patient selection and close monitoring for potential adverse effects. It's a reminder that even in the realm of advanced medications, there are always nuances to consider, much like the varying terrain of the desert landscape.

Balancing Benefits and Risks

The research reveals the need for careful consideration of both the benefits and risks associated with PER. The study highlights the importance of patient education and open communication between healthcare providers and patients to ensure informed decision-making.

Dr. Camel's Conclusion

This research underscores the ongoing quest for more effective and well-tolerated treatments for epilepsy. It's a reminder that finding the right medication for each individual is a journey that requires careful navigation, much like a camel traversing a vast and unpredictable desert. The study highlights the importance of personalized medicine and the need to carefully weigh the potential benefits and risks of each treatment option.