Dacomitinib, a pan-inhibitor of ErbB receptors, suppresses growth and invasive capacity of chemoresistant ovarian carcinoma cells.

Author: AlimoghaddamKamran, AlishahiZivar, BarghiFarinaz, BashashDavood, ChahardouliBahram, DardaeiLeila, DehpourAhmad R, EsmaeiliFatemeh, EyvaniHaniyeh, GhaffariSeyed H, GhasemiReza, GhavamzadehArdeshir, MirshahvaladiShahab, MoghaddaskhoFarima, MomenyMajid, PoursheikhaniArash, SabourinejadZahra, SankanianGhazaleh, Tavakkoly-BazzazJavad, YousefiHassan, ZaghalAzam, ZarrinradGhazaleh

Paper Details 
Original Abstract of the Article :
Epithelial ovarian cancer (EOC) is the most lethal gynaecological malignancy worldwide. Development of chemoresistance and peritoneal dissemination of EOC cells are the major reasons for low survival rate. Targeting signal transduction pathways which promote therapy resistance and metastatic dissemi...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482808/

データ提供:米国国立医学図書館(NLM)

Tackling Chemoresistance in Ovarian Cancer: Dacomitinib Shows Promise

The fight against [epithelial ovarian cancer (EOC)] is a challenging one, as the disease often develops resistance to chemotherapy and spreads rapidly. This study explores the potential of [dacomitinib, a pan-ErbB receptor inhibitor], as a novel treatment strategy for chemoresistant EOC. The authors investigated dacomitinib's ability to [inhibit tumor growth, reduce invasive capacity, and induce apoptosis in chemoresistant EOC cells]. Their findings suggest that dacomitinib could be a promising therapeutic option for patients with this aggressive form of cancer.

Targeting Multiple Pathways: A New Strategy

This research highlights the importance of [targeting multiple signaling pathways simultaneously] to combat chemoresistance in EOC. Dacomitinib's ability to [inhibit the ErbB family of receptors] effectively addresses the multiple mechanisms that contribute to chemoresistance and invasiveness. The study's findings suggest that [this multifaceted approach could lead to more effective treatment outcomes].

Hope for Chemoresistant Ovarian Cancer

This research provides a glimmer of hope for patients with [chemoresistant EOC], a challenging condition with limited treatment options. Dacomitinib's promising activity against chemoresistant EOC cells [suggests that further research and clinical trials are warranted to evaluate its potential as a viable treatment option].

Dr.Camel's Conclusion

Just as a camel adapts to the harsh desert environment, researchers are finding innovative ways to combat chemoresistance in EOC. Dacomitinib's ability to target multiple pathways simultaneously offers a promising new strategy for treating this challenging disease. This research encourages optimism and motivates continued exploration of targeted therapies for chemoresistant cancers.

Date :
  1. Date Completed 2019-01-18
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

28646172

DOI: Digital Object Identifier

PMC5482808

Related Literature

SNS
PICO Info
in preparation
Languages

English

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