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The Cardiovascular Pharmacology of Nonsteroidal Anti-Inflammatory Drugs.

Author: FitzGeraldGarret A, GrosserTilo, RicciottiEmanuela

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This study discusses the cardiovascular (CV) safety profile of nonsteroidal anti-inflammatory drugs (NSAIDs), particularly comparing celecoxib, a cyclooxygenase-2-selective NSAID, to traditional NSAIDs. The study concludes that celecoxib may have a higher CV risk than traditional NSAIDs and that the two large clinical trials that compared the two types of NSAIDs may have underestimated the CV risk of celecoxib.
Paper Details　
Original Abstract of the Article :
The principal molecular mechanisms underlying the cardiovascular (CV) and renal adverse effects of nonsteroidal anti-inflammatory drugs (NSAIDs), such as myocardial infarction and hypertension, are understood in more detail than most side effects of drugs. Less is known, however, about differences i...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/28651847

データ提供：米国国立医学図書館（NLM）

NSAIDs and Cardiovascular Health: A Journey Through Pharmacological Landscapes

The world of nonsteroidal anti-inflammatory drugs (NSAIDs) is a vast and complex landscape, with each drug possessing unique properties and potential side effects. This study, like a meticulous cartographer charting a new terrain, examines the cardiovascular (CV) effects of NSAIDs, exploring the intricate relationship between these medications and heart health. The study focuses on the molecular mechanisms underlying the CV risks associated with NSAIDs, including myocardial infarction and hypertension, highlighting the importance of understanding the nuances of drug interactions and individual patient profiles.

Navigating the Landscape of NSAID Safety

The study underscores the importance of recognizing that not all NSAIDs are created equal. The authors delve into the pharmacokinetics and pharmacodynamics of different NSAIDs, highlighting the need to understand the unique profiles of each drug. This study acts as a guide through the diverse pharmacological terrain, helping to identify the potential risks and benefits associated with different NSAIDs.

Choosing the Right Path: Weighing Risks and Benefits

The research emphasizes the importance of carefully weighing the risks and benefits of NSAID use, particularly for individuals with pre-existing cardiovascular conditions. The authors stress the need for individualized care, ensuring that each patient's journey is tailored to their unique needs and risk factors. It's like choosing the safest route across a vast desert – each traveler's needs must be considered to ensure a smooth and successful journey.

Dr.Camel's Conclusion

This study provides valuable insights into the complex relationship between NSAIDs and cardiovascular health. By understanding the nuances of these medications and their potential effects on the heart, healthcare professionals can make informed decisions, ensuring that patients navigate the therapeutic landscape with confidence and safety.

Date :
  1. Date Completed 2017-10-30
  2. Date Revised 2022-03-31
Further Info :

Pubmed ID

28651847

DOI: Digital Object Identifier

NIHMS887947

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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