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Sulfasalazine-Induced Crystalluria Causing Severe Acute Kidney Injury.

Author: DurandoMichael, KimJames Soo, TiuHannah

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study reports a case of severe acute kidney injury and nephrolithiasis in a patient with Crohn's disease who was treated with sulfasalazine for over 10 years. The case highlights the potential for renal complications, specifically nephrolithiasis, with sulfasalazine therapy and emphasizes the importance of hydration in patients on sulfasalazine.
Paper Details　
Original Abstract of the Article :
Sulfasalazine is an anti-inflammatory agent commonly used in the treatment of autoimmune conditions such as inflammatory bowel disease and rheumatoid arthritis. Sulfasalazine is converted by gut bacteria into sulfapyridine and the clinically active metabolite 5-aminosalicylic acid (5-ASA), and its e...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
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引用元：
https://doi.org/10.1053/j.ajkd.2017.05.013

データ提供：米国国立医学図書館（NLM）

Sulfasalazine-Induced Crystalluria Causing Severe Acute Kidney Injury

The field of [renal complications] is always looking for new ways to understand and treat [kidney problems]. This study delves into a specific issue, [sulfasalazine-induced crystalluria], which can be a real pain for those with [inflammatory bowel disease]. The authors used [case report] to study the effects of [sulfasalazine] on kidney health. They found that [sulfasalazine] can cause [kidney stones], which can lead to [severe acute kidney injury]. The importance of this study lies in the fact that [renal complications] from [sulfasalazine] may not be as well-known as they should be. This emphasizes the need for [close monitoring of patients on sulfasalazine].

Sulfasalazine and Kidney Stones: A Delicate Balance

The study's results suggest that [sulfasalazine] can be a double-edged sword. While it helps [fight inflammation] in conditions like [inflammatory bowel disease], it can also lead to [kidney stones]. The authors point out the crucial role of [hydration] in preventing these complications.

Stay Hydrated, Keep Your Kidneys Happy

This research highlights the importance of [staying hydrated] for anyone taking [sulfasalazine]. Just like a camel needs water to traverse the vast desert, our kidneys need plenty of fluids to function optimally. Drinking enough water can help flush out potential kidney stone-forming substances, keeping those precious organs healthy.

Dr.Camel's Conclusion

This research is a reminder that even seemingly safe medications can have unexpected side effects. Like a mirage in the desert, sometimes what we think we know about medications can be deceiving. It's crucial to stay informed and work closely with our healthcare providers to manage any potential complications.

Date :
  1. Date Completed 2017-12-05
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

28669550

DOI: Digital Object Identifier

10.1053/j.ajkd.2017.05.013

SNS
PICO Info
in preparation
Languages

English

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