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Ethanol extract of Ilex hainanensis Merr. exhibits anti-melanoma activity by induction of G<sub>1</sub>/S cell-cycle arrest and apoptosis.

Author: LiuChang, LiuYun-Xing, ShenYan-Jun, SunWei-Dong, SunYun, WangJuan, YangHao, YinMin-Qiang, ZhangBao-Yuan, ZhangYa-Qi

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

IME exhibited significant anti-melanoma activity in vitro and in vivo, suggesting that IME might be a promising effective candidate with lower toxic for malignant melanoma therapy.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To evaluate anti-melanoma effect of ethanol extract of Ilex hainanensis Merr. (IME) and elucidate its underlying mechanism. METHODS: Thirty-six tumor-bearing mice were randomized into 6 groups (n=6) as follows: model group, IME 25, 50, 100, and 200 mg/kg groups and dacarbazine (DTIC) 70 ...See full text at original site
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引用元：
https://doi.org/10.1007/s11655-017-2544-8

データ提供：米国国立医学図書館（NLM）

Ilex Hainanensis Merr: A Potential Oasis in the Desert of Melanoma

Melanoma, a dangerous form of skin cancer, often presents a formidable challenge for medical professionals. This research explores the potential of a natural compound, ethanol extract of Ilex hainanensis Merr. (IME), as a new weapon in the fight against melanoma.

The researchers conducted a series of in vitro and in vivo experiments to evaluate IME's anti-melanoma activity. Their findings suggest that IME effectively inhibits the proliferation of melanoma cells by inducing cell cycle arrest and apoptosis. This is like discovering a hidden oasis in the desert of melanoma, offering a potential source of relief and hope for patients.

A New Avenue for Melanoma Treatment

The study's findings suggest that IME may be a promising candidate for treating melanoma. Its ability to induce cell cycle arrest and apoptosis could lead to a significant improvement in patient outcomes. This is a beacon of hope shining brightly in the desert of melanoma.

Harnessing the Power of Nature to Fight Melanoma

This research demonstrates the potential of natural compounds like IME as effective treatment options for cancer. It encourages further investigation into the therapeutic properties of natural substances, potentially leading to the development of new and effective cancer therapies. It's like exploring the diverse landscapes of nature, seeking out hidden treasures that can benefit human health.

Dr. Camel's Conclusion

This study showcases the promising potential of Ilex hainanensis Merr. as a natural anti-melanoma agent. It's a testament to the vast therapeutic potential that lies within the natural world, waiting to be discovered and harnessed for the benefit of human health.

Date :
  1. Date Completed 2018-08-27
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

28741062

DOI: Digital Object Identifier

10.1007/s11655-017-2544-8

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・Side Effects of dacarbazine
SNS
PICO Info
in preparation
Languages

English

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