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No Effect of Levothyroxine and Levothyroxine-Induced Subclinical Thyrotoxicosis on the Pharmacokinetics of Sorafenib in Healthy Male Subjects.
Author: AjavonAntoinette, BerseMatthias, HuangErya, HuangFunan, LettieriJohn, LiuRong, PeñaCarol
Original Abstract of the Article :
Patients receiving the multikinase inhibitor sorafenib for locally recurrent or metastatic, progressive, differentiated thyroid carcinoma (DTC) refractory to radioactive iodine often receive concomitant levothyroxine for thyrotropin (TSH) suppression. In the Phase 3 DTC trial (DECISION), sorafenib e...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646750/
データ提供:米国国立医学図書館(NLM)
Sorafenib and Levothyroxine: A Desert Oasis of Compatibility
This study delves into the world of drug interactions, specifically examining the potential interplay between sorafenib, a multikinase inhibitor used for thyroid cancer, and levothyroxine, a medication for hypothyroidism. It investigates whether levothyroxine or levothyroxine-induced subclinical thyrotoxicosis, a condition where thyroid hormone levels are slightly elevated, affects the pharmacokinetics of sorafenib. The researchers sought to understand whether these medications interact and potentially alter the effectiveness of sorafenib treatment.
A Harmonious Partnership: Sorafenib and Levothyroxine
The study found no significant interaction between sorafenib and levothyroxine, indicating that these medications can be safely used together. This discovery is reassuring for patients receiving both medications, as it suggests that levothyroxine treatment does not compromise the effectiveness of sorafenib. It's like finding a hidden oasis where two weary travelers can rest and replenish their supplies, without interfering with each other's journeys.
A Safe Passage: Navigating Thyroid Cancer Treatment
This research provides valuable information for patients with thyroid cancer who are receiving both sorafenib and levothyroxine. It confirms that these medications can be safely used together, ensuring that patients can effectively manage both their thyroid condition and their cancer treatment. It's like finding a clear path through a desert, enabling a safe and successful journey toward recovery.
Dr. Camel's Conclusion
This study demonstrates the compatibility of sorafenib and levothyroxine, offering reassurance for patients receiving both medications. It's a journey toward effective and safe treatment, ensuring a smooth and successful passage through the challenges of thyroid cancer.
Date :
- Date Completed 2018-05-22
- Date Revised 2018-12-02
Further Info :
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