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Long-term corneal endothelial cell loss after cataract surgery. Results of a randomized controlled trial. Oxford Cataract Treatment and Evaluation Team (OCTET).

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Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.

Overview

This study compared the long-term effects of three cataract surgery methods: (A) intracapsular extraction with contact lens, (B) intracapsular extraction with an implanted lens, and (C) extracapsular extraction with an implanted lens. The study found that both groups with implanted lenses experienced greater loss of corneal cells than the group without implants, especially after one year. Cell loss slowed down after the third year, except in the group with intracapsular extraction and an implanted lens, where cell loss was related to complications. The use of alpha-chymotrypsin during surgery reduced cell loss, while contact lenses after surgery increased it. Complications like inflammation, lens displacement, shallow anterior chamber, and fluid buildup in the macula were also associated with greater cell loss. The study highlights that while lens implantation can be effective for cataracts, it can lead to significant corneal cell loss over time, and complications can worsen this effect.
Paper Details　
Original Abstract of the Article :
Three hundred thirty-three eyes were randomly assigned to three treatments for cataract: group A, intracapsular extraction plus contact lens; group B, intracapsular extraction plus Federov implant (Federov I lenses were made by Rayners Ltd, United Kingdom, based on a design by Professor Fyodorov); a...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2874782

データ提供：米国国立医学図書館（NLM）

Long-Term Corneal Endothelial Cell Loss After Cataract Surgery

Imagine the delicate and intricate structure of the cornea, the clear front window of your eye. This study investigated the long-term impact of different cataract surgery techniques on the corneal endothelial cells, responsible for maintaining corneal clarity. The researchers conducted a randomized controlled trial, dividing participants into three groups: one receiving intracapsular extraction with a contact lens, another receiving intracapsular extraction with an implant, and the third receiving extracapsular extraction with an iridocapsular implant. They followed the participants for up to four years, carefully monitoring the loss of corneal endothelial cells over time.

Long-Term Impact of Cataract Surgery Techniques

The study revealed that both implant groups experienced significantly greater endothelial cell loss compared to the contact lens group, particularly after the first year. The study also identified factors like the use of alpha-chymotrypsin and postoperative complications that significantly influenced cell loss. This research underscores the importance of carefully considering the potential risks and benefits of different cataract surgery techniques to minimize the risk of long-term complications.

Protecting Your Vision: A Long-Term Perspective

This study highlights the long-term consequences of different surgical interventions, even those seemingly minor like cataract surgery. It emphasizes the importance of discussing your individual needs and concerns with your ophthalmologist, considering not only the immediate benefits of surgery but also the potential long-term impacts on your vision. Just as a camel conserves its water for a long desert journey, it's essential to make informed choices that protect your vision for the long haul.

Dr.Camel's Conclusion

This research reminds us that even the most common surgical procedures can have unforeseen consequences. It underscores the importance of considering the long-term implications of medical interventions, weighing the immediate benefits against the potential for future complications. By being informed and proactive, we can strive for the best possible outcomes for our vision health.

Date :
  1. Date Completed 1986-09-17
  2. Date Revised 2015-04-17
Further Info :

Pubmed ID

2874782

DOI: Digital Object Identifier

2874782

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・Effective treatment of cataract
SNS
PICO Info
in preparation
Languages

English

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