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Assessment of inhibitory effects on major human cytochrome P450 enzymes by spasmolytics used in the treatment of overactive bladder syndrome.
Author: AslanSevinc, DahlingerDominik, FrechenSebastian, FuhrUwe, PietschMarkus
Original Abstract of the Article :
The objective of this study was to examine the inhibitory potential of darifenacin, fesoterodine, oxybutynin, propiverine, solifenacin, tolterodine and trospium chloride on the seven major human cytochrome P450 enzymes (CYP) by using a standardized and validated seven-in-one cytochrome P450 cocktail...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510770/
データ提供:米国国立医学図書館(NLM)
Spasmolytics and Cytochrome P450: A Chemical Oasis in the Desert of Overactive Bladder
This study delves into the fascinating world of spasmolytics, a group of drugs used to treat overactive bladder. These medications are like a welcome oasis in the desert of bladder discomfort. They calm the muscles of the bladder, helping to reduce the frequency and urgency of urination. This study examines how these drugs interact with cytochrome P450 (CYP), a group of enzymes that play a crucial role in drug metabolism.
A Chemical Dance: Spasmolytics and Cytochrome P450
Think of CYP as a bustling marketplace in the desert. Different drugs, like our spasmolytics, come to this marketplace to be processed and broken down. This study looks at how these drugs interact with the CYP enzymes, which can sometimes lead to unexpected interactions and effects.
Navigating the Chemical Oasis: Understanding the Implications
By understanding how spasmolytics interact with the CYP enzymes, healthcare providers can make more informed decisions about how to best use these drugs. This research helps us create a map of this chemical oasis, ensuring that patients can benefit from the oasis without experiencing any unwanted side effects.
Dr.Camel's Conclusion
This study helps us understand the complex dance between spasmolytics and CYP enzymes. It's like carefully navigating a chemical oasis, making sure that the benefits outweigh the risks. By understanding these interactions, we can ensure that patients with overactive bladder get the relief they need, safely and effectively.
Date :
- Date Completed n.d.
- Date Revised 2020-09-30
Further Info :
Related Literature
English
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