Effects of Vitamin D<sub>2</sub> Supplementation on Vitamin D<sub>3</sub> Metabolism in Health and CKD.

Author: BatacchiZona, HoofnagleAndrew N, IsakovaTamara, KestenbaumBryan, MartinKevin J, Robinson-CohenCassianne, WolfMyles S, de BoerIan H

Paper Details 
Original Abstract of the Article :
Label="BACKGROUND AND OBJECTIVES" NlmCategory="OBJECTIVE">Vitamin D supplements are prescribed to correct low circulating concentrations of 25-hydroxyvitamin D. In CKD, vitamin D metabolism is complicated by decreased conversion of 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D by CYP27B1 and possib...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586563/

データ提供:米国国立医学図書館(NLM)

Vitamin D Supplementation: A Complex Puzzle in Health and CKD

Vitamin D supplementation is a common practice for correcting low circulating levels of vitamin D, but its impact on vitamin D metabolism can be complex, especially in individuals with chronic kidney disease (CKD). This study explores the effects of vitamin D2 supplementation on vitamin D metabolism in both healthy individuals and those with CKD. Think of vitamin D metabolism as a delicate balance in a desert ecosystem, where different factors interact to maintain equilibrium.

The study aimed to understand how vitamin D2 supplementation affects the conversion of different forms of vitamin D in both healthy individuals and those with CKD. It's like comparing the effects of rainfall on two distinct desert landscapes – one lush and fertile, the other barren and challenging.

A Complicated Balance

The study highlights the complexities of vitamin D metabolism, particularly in CKD, where the conversion of 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D, the active form of vitamin D, is impaired. It's like a desert oasis struggling to maintain its water supply due to a drought. The researchers emphasize the need for further research to optimize vitamin D supplementation strategies for individuals with CKD.

Vitamin D: A Vital Desert Nutrient

It's important to consult with your doctor to determine the appropriate vitamin D supplementation for your individual needs. Just as a desert traveler needs to replenish their water supply, individuals with low vitamin D levels might benefit from supplementation. However, it's crucial to follow your doctor's guidance to avoid potential adverse effects.

Dr.Camel's Conclusion

This research emphasizes the importance of personalized approaches to vitamin D supplementation, taking into account individual health status and metabolic pathways. Just as the desert landscape can be diverse and unpredictable, vitamin D metabolism requires a nuanced understanding to ensure optimal outcomes. Remember, maintaining a healthy desert ecosystem requires a balanced approach to water, nutrients, and environmental factors. Similarly, achieving optimal vitamin D levels involves a collaborative effort between individuals and healthcare providers.

Date :
  1. Date Completed 2018-05-21
  2. Date Revised 2023-08-13
Further Info :

Pubmed ID

28768705

DOI: Digital Object Identifier

PMC5586563

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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