Ultrasound Improves the Delivery and Therapeutic Effect of Nanoparticle-Stabilized Microbubbles in Breast Cancer Xenografts.

Author: BergSigrid, BjørkøyAstrid, DaviesCatharina de Lange, GrimstadIngeborg, HansenRune, MaalandAstri F, MørchÝrr, SnipstadSofie, SulheimEinar, TorpSverre H, van WamelAnnemieke

Paper Details 
Original Abstract of the Article :
Compared with conventional chemotherapy, encapsulation of drugs in nanoparticles can improve efficacy and reduce toxicity. However, delivery of nanoparticles is often insufficient and heterogeneous because of various biological barriers and uneven tumor perfusion. We investigated a unique multifunct...See full text at original site
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引用元:
https://doi.org/10.1016/j.ultrasmedbio.2017.06.029

データ提供:米国国立医学図書館(NLM)

Ultrasound: A Guiding Light in the Desert of Drug Delivery

The delivery of nanoparticles, like navigating a sandstorm, often faces challenges due to biological barriers and uneven tumor perfusion. This research investigates a novel drug delivery system involving microbubbles stabilized by polymeric nanoparticles (NPMBs) and ultrasound-mediated drug delivery. The authors explore the potential of ultrasound to enhance the delivery and therapeutic efficacy of nanoparticles in breast cancer xenografts.

Ultrasound: A Powerful Tool for Drug Delivery

The study demonstrates the effectiveness of ultrasound in improving nanoparticle delivery to tumors. The authors found that ultrasound-mediated delivery of NPMBs significantly enhanced tumor uptake, leading to a promising therapeutic effect. The researchers observed complete tumor regression in a proof-of-concept study, highlighting the potential of this technique for enhancing drug delivery and cancer treatment.

Precision Targeting: A Mirage or a Reality?

The study suggests that ultrasound can be used to precisely target drug delivery to tumors, improving efficacy and minimizing side effects. This approach, similar to a traveler using a map to navigate the desert, offers the potential to improve treatment outcomes and minimize the toxicity associated with conventional chemotherapy.

Dr.Camel's Conclusion

This research is a testament to the transformative power of technology in the desert of medicine. The use of ultrasound-mediated delivery of nanoparticles holds great promise for revolutionizing cancer treatment. Just as a skilled traveler uses a compass to navigate the desert, so too must we embrace innovative tools to find our way towards more effective and precise therapies.

Date :
  1. Date Completed 2018-06-14
  2. Date Revised 2021-01-03
Further Info :

Pubmed ID

28781149

DOI: Digital Object Identifier

10.1016/j.ultrasmedbio.2017.06.029

Related Literature

SNS
PICO Info
in preparation
Languages

English

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