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Pneumococcal vaccination in patients with systemic lupus erythematosus: A multicenter placebo-controlled randomized double-blind study.

Author: , BahuaudMathilde, BatteuxFrédéric, Costedoat-ChalumeauNathalie, GrabarSophie, GrohMatthieu, GuillevinLoïc, HanslikThomas, LaunayOdile, Le GuernVéronique, MathianAlexis

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Sequential immunization with the 7-valent pneumococcal conjugate (PnCj) vaccine followed by the 23-valent polysaccharide (PPS) vaccine was more effective and safe than PPS vaccination alone in patients with systemic lupus erythematosus (SLE).
Paper Details　
Original Abstract of the Article :
Invasive pneumococcal disease and respiratory tract infections are both frequent and severe in patients with systemic lupus erythematosus (SLE). This study aimed to compare the immunological efficacy and safety of pneumococcal vaccination with the 23-valent polysaccharide (PPS) vaccine alone to a se...See full text at original site
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引用元：
https://doi.org/10.1016/j.vaccine.2017.07.094

データ提供：米国国立医学図書館（NLM）

Exploring the Efficacy and Safety of Pneumococcal Vaccination in Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE), an autoimmune disorder, weakens the immune system, making individuals susceptible to infections. This study investigates the efficacy and safety of pneumococcal vaccination in patients with SLE, comparing the effectiveness of different vaccination strategies. The researchers conducted a multicenter, placebo-controlled, randomized, double-blind trial, evaluating the immune response and safety of pneumococcal vaccination in patients with SLE.

Pneumococcal Vaccination: A Promising Strategy for SLE Patients

This study provides valuable data on the efficacy and safety of pneumococcal vaccination in SLE patients, suggesting that it is a viable strategy for preventing pneumococcal disease. The researchers found that pneumococcal vaccination was well-tolerated and elicited a robust immune response in SLE patients. This finding provides hope for improving the health outcomes of SLE patients, reducing their risk of severe pneumococcal infections. It's like discovering a hidden oasis in the vast desert of autoimmune diseases, a source of protection against infections.

Protecting SLE Patients from Pneumococcal Infections

This research emphasizes the importance of proactive measures to protect individuals with SLE from potentially life-threatening infections. The study highlights the efficacy and safety of pneumococcal vaccination, reminding us that preventative strategies are essential in managing autoimmune disorders. This research serves as a reminder that in the vast and unforgiving desert of autoimmune disease, preventative measures can offer a lifeline of protection.

Dr.Camel's Conclusion

The desert of autoimmune disease can be a harsh and unforgiving place, where the immune system turns against its own body. This research, like a cool breeze across the desert sands, offers hope for individuals living with SLE. The findings show that pneumococcal vaccination is a safe and effective way to protect SLE patients from potentially life-threatening infections. It's a reminder that even in the face of complex medical challenges, proactive steps can make a significant difference in improving patient outcomes.

Date :
  1. Date Completed 2018-03-12
  2. Date Revised 2018-04-03
Further Info :

Pubmed ID

28784280

DOI: Digital Object Identifier

10.1016/j.vaccine.2017.07.094

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・Effects of pneumococcal polysaccharide vaccine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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